Relationship between the surface roughness of biodegradable mg-based bulk metallic glass and the osteogenetic ability of mg63 osteoblast-like cells

Pei Chun Wong, Sin Mao Song, Pei Hua Tsai, Yi Yuan Nien, Jason Shian Ching Jang, Cheng Kung Cheng, Chih Hwa Chen

研究成果: 雜誌貢獻文章

摘要

Mg-based bulk metallic glass materials have been investigated for their large potential for application in orthopedic implants due to their biocompatibility, low degradation rate, and osteogenetic ability. As an orthopedic implant, initial cell adhesion has been a critical issue for subsequent osteogenesis and bone formation because the first contact between cells and the implant occurs upon the implants surface. Here, we aimed to create Mg-based bulk metallic glass samples with three different surface roughness attributes in order to understand the degradation behavior of Mg-based bulk metallic glass and the adhesion ability and osteogenetic ability of the contact cells. It was found that the degradation behavior of Mg66Zn29Ca5 bulk metallic glass was not affected by surface roughness. The surface of the Mg66Zn29Ca5 bulk metallic glass samples polished via #800 grade sandpaper was found to offer a well-attached surface and to provide a good cell viability environment for Human MG63 osteoblast-like cell line. In parallel, more calcium and mineral deposition was investigated on extracellular matrix with higher surface roughness that verify the relationship between surface roughness and cell performance.

原文英語
文章編號1188
期刊Materials
13
發行號5
DOIs
出版狀態已發佈 - 三月 1 2020

ASJC Scopus subject areas

  • Materials Science(all)

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