Relation of C-Reactive Protein and Carotid Intima Media Thickness in Taiwanese With Familial Hypercholesterolemia

Zhong Xuan Ye, Hao Ming Cheng, Kuan Rau Chiou, Min Ji Charng

研究成果: 雜誌貢獻文章

10 引文 (Scopus)

摘要

The aim of this study was to investigate the potential relationships between the carotid intima media thickness (carotid IMT), high sensitive C-reactive protein (hsCRP), and cholesterol burden in heterozygous familial hypercholesterolemia (FH) subjects. Thirty-two genetically-verified heterozygous patients with FH and 34 healthy controls were recruited into our study in Taiwan. We measured conventional risk factors, hsCRP, and carotid IMT of study subjects. The cholesterol-year score was used to estimate the lifetime cholesterol burden. Subjects with heterozygous FH had significantly elevated total cholesterol, elevated low-density lipoprotein cholesterol, and increased carotid IMT compared with control subjects. Carotid IMT correlated well with the cholesterol-year score. In patients with FH, univariate analysis showed that hsCRP was highly correlated with carotid IMT. Multiple linear regression analysis indicated that hsCRP was the only independent predictor of carotid IMT in patients with FH. In conclusion, patients with heterozygous FH had significantly higher carotid IMT and the level of hsCRP was independently associated with atherosclerotic progression. (R: 0.639, R2: 0.408, p

原文英語
頁(從 - 到)184-187
頁數4
期刊American Journal of Cardiology
102
發行號2
DOIs
出版狀態已發佈 - 七月 15 2008

指紋

Carotid Intima-Media Thickness
Hyperlipoproteinemia Type II
C-Reactive Protein
Cholesterol
Hypercholesterolemia
Taiwan
LDL Cholesterol
Linear Models
Regression Analysis

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine

引用此文

Relation of C-Reactive Protein and Carotid Intima Media Thickness in Taiwanese With Familial Hypercholesterolemia. / Ye, Zhong Xuan; Cheng, Hao Ming; Chiou, Kuan Rau; Charng, Min Ji.

於: American Journal of Cardiology, 卷 102, 編號 2, 15.07.2008, p. 184-187.

研究成果: 雜誌貢獻文章

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abstract = "The aim of this study was to investigate the potential relationships between the carotid intima media thickness (carotid IMT), high sensitive C-reactive protein (hsCRP), and cholesterol burden in heterozygous familial hypercholesterolemia (FH) subjects. Thirty-two genetically-verified heterozygous patients with FH and 34 healthy controls were recruited into our study in Taiwan. We measured conventional risk factors, hsCRP, and carotid IMT of study subjects. The cholesterol-year score was used to estimate the lifetime cholesterol burden. Subjects with heterozygous FH had significantly elevated total cholesterol, elevated low-density lipoprotein cholesterol, and increased carotid IMT compared with control subjects. Carotid IMT correlated well with the cholesterol-year score. In patients with FH, univariate analysis showed that hsCRP was highly correlated with carotid IMT. Multiple linear regression analysis indicated that hsCRP was the only independent predictor of carotid IMT in patients with FH. In conclusion, patients with heterozygous FH had significantly higher carotid IMT and the level of hsCRP was independently associated with atherosclerotic progression. (R: 0.639, R2: 0.408, p",
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