Two new abietane type diterpenoids, namely seco-helioscopinolide (1) and 3β,7β-dihydroxy-ent-abieta-8,13-diene-12,16-olide (2) were isolated from the aerial parts of Euphorbia formosana Hayata together with helioscopinolide A (3), helioscopinolide B (4), helioscopinolide C (5) and ent-(5β,8α,9β,10α,12α)-12-hydroxyatis-16-ene-3, 14-dione (6). The structures of compounds 1-6 were elucidated by analyzing their spectroscopic data and comparison with the literature. Further biological tests by gelatin zymographic analysis revealed that 3-5 significantly up-regulated the expressions and activation of MMP-2 and -9 in human fibrosarcoma cell line HT1080.
ASJC Scopus subject areas
- Organic Chemistry
Yu, C. C., Hsieh, C. R., Hsiao, G., Chen, P. Y., Chang, M. L., Yin, H. W., Li, Z-H., & Lee, C. K. (2012). Regulated expressions of MMP-2, -9 by diterpenoids from Euphorbia formosana hayata. Molecules, 17(2), 2082-2090. https://doi.org/10.3390/molecules17022082