Regulated expressions of MMP-2, -9 by diterpenoids from Euphorbia formosana hayata

Chia Chun Yu, Ching Ruey Hsieh, George Hsiao, Pi Yu Chen, Meng Lun Chang, Hwa Wen Yin, Zong-Huei Li, Ching Kuo Lee

研究成果: 雜誌貢獻文章

10 引文 斯高帕斯(Scopus)

摘要

Two new abietane type diterpenoids, namely seco-helioscopinolide (1) and 3β,7β-dihydroxy-ent-abieta-8,13-diene-12,16-olide (2) were isolated from the aerial parts of Euphorbia formosana Hayata together with helioscopinolide A (3), helioscopinolide B (4), helioscopinolide C (5) and ent-(5β,8α,9β,10α,12α)-12-hydroxyatis-16-ene-3, 14-dione (6). The structures of compounds 1-6 were elucidated by analyzing their spectroscopic data and comparison with the literature. Further biological tests by gelatin zymographic analysis revealed that 3-5 significantly up-regulated the expressions and activation of MMP-2 and -9 in human fibrosarcoma cell line HT1080.
原文英語
頁(從 - 到)2082-2090
頁數9
期刊Molecules
17
發行號2
DOIs
出版狀態已發佈 - 二月 2012

ASJC Scopus subject areas

  • Organic Chemistry

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