Regulated expressions of MMP-2, -9 by diterpenoids from Euphorbia formosana hayata

Chia Chun Yu, Ching Ruey Hsieh, George Hsiao, Pi Yu Chen, Meng Lun Chang, Hwa Wen Yin, Zong-Huei Li, Ching Kuo Lee

研究成果: 雜誌貢獻文章

10 引文 (Scopus)

摘要

Two new abietane type diterpenoids, namely seco-helioscopinolide (1) and 3β,7β-dihydroxy-ent-abieta-8,13-diene-12,16-olide (2) were isolated from the aerial parts of Euphorbia formosana Hayata together with helioscopinolide A (3), helioscopinolide B (4), helioscopinolide C (5) and ent-(5β,8α,9β,10α,12α)-12-hydroxyatis-16-ene-3, 14-dione (6). The structures of compounds 1-6 were elucidated by analyzing their spectroscopic data and comparison with the literature. Further biological tests by gelatin zymographic analysis revealed that 3-5 significantly up-regulated the expressions and activation of MMP-2 and -9 in human fibrosarcoma cell line HT1080.
原文英語
頁(從 - 到)2082-2090
頁數9
期刊Molecules
17
發行號2
DOIs
出版狀態已發佈 - 二月 2012

指紋

Abietane Diterpenes
Euphorbia
Diterpenes
Fibrosarcoma
gelatins
Dione
dienes
Gelatin
Matrix Metalloproteinases
cultured cells
Chemical activation
Cells
activation
Antennas
Cell Line
helioscopinolide B
helioscopinolide A

ASJC Scopus subject areas

  • Organic Chemistry

引用此文

Regulated expressions of MMP-2, -9 by diterpenoids from Euphorbia formosana hayata. / Yu, Chia Chun; Hsieh, Ching Ruey; Hsiao, George; Chen, Pi Yu; Chang, Meng Lun; Yin, Hwa Wen; Li, Zong-Huei; Lee, Ching Kuo.

於: Molecules, 卷 17, 編號 2, 02.2012, p. 2082-2090.

研究成果: 雜誌貢獻文章

Yu, CC, Hsieh, CR, Hsiao, G, Chen, PY, Chang, ML, Yin, HW, Li, Z-H & Lee, CK 2012, 'Regulated expressions of MMP-2, -9 by diterpenoids from Euphorbia formosana hayata', Molecules, 卷 17, 編號 2, 頁 2082-2090. https://doi.org/10.3390/molecules17022082
Yu, Chia Chun ; Hsieh, Ching Ruey ; Hsiao, George ; Chen, Pi Yu ; Chang, Meng Lun ; Yin, Hwa Wen ; Li, Zong-Huei ; Lee, Ching Kuo. / Regulated expressions of MMP-2, -9 by diterpenoids from Euphorbia formosana hayata. 於: Molecules. 2012 ; 卷 17, 編號 2. 頁 2082-2090.
@article{10e41c7caa3f4a349ffd4a4254a986fb,
title = "Regulated expressions of MMP-2, -9 by diterpenoids from Euphorbia formosana hayata",
abstract = "Two new abietane type diterpenoids, namely seco-helioscopinolide (1) and 3β,7β-dihydroxy-ent-abieta-8,13-diene-12,16-olide (2) were isolated from the aerial parts of Euphorbia formosana Hayata together with helioscopinolide A (3), helioscopinolide B (4), helioscopinolide C (5) and ent-(5β,8α,9β,10α,12α)-12-hydroxyatis-16-ene-3, 14-dione (6). The structures of compounds 1-6 were elucidated by analyzing their spectroscopic data and comparison with the literature. Further biological tests by gelatin zymographic analysis revealed that 3-5 significantly up-regulated the expressions and activation of MMP-2 and -9 in human fibrosarcoma cell line HT1080.",
keywords = "Abietane diterpene, Euphorbia formosana, HT-1080, MMP-2, -9",
author = "Yu, {Chia Chun} and Hsieh, {Ching Ruey} and George Hsiao and Chen, {Pi Yu} and Chang, {Meng Lun} and Yin, {Hwa Wen} and Zong-Huei Li and Lee, {Ching Kuo}",
year = "2012",
month = "2",
doi = "10.3390/molecules17022082",
language = "English",
volume = "17",
pages = "2082--2090",
journal = "Molecules",
issn = "1420-3049",
publisher = "Multidisciplinary Digital Publishing Institute (MDPI)",
number = "2",

}

TY - JOUR

T1 - Regulated expressions of MMP-2, -9 by diterpenoids from Euphorbia formosana hayata

AU - Yu, Chia Chun

AU - Hsieh, Ching Ruey

AU - Hsiao, George

AU - Chen, Pi Yu

AU - Chang, Meng Lun

AU - Yin, Hwa Wen

AU - Li, Zong-Huei

AU - Lee, Ching Kuo

PY - 2012/2

Y1 - 2012/2

N2 - Two new abietane type diterpenoids, namely seco-helioscopinolide (1) and 3β,7β-dihydroxy-ent-abieta-8,13-diene-12,16-olide (2) were isolated from the aerial parts of Euphorbia formosana Hayata together with helioscopinolide A (3), helioscopinolide B (4), helioscopinolide C (5) and ent-(5β,8α,9β,10α,12α)-12-hydroxyatis-16-ene-3, 14-dione (6). The structures of compounds 1-6 were elucidated by analyzing their spectroscopic data and comparison with the literature. Further biological tests by gelatin zymographic analysis revealed that 3-5 significantly up-regulated the expressions and activation of MMP-2 and -9 in human fibrosarcoma cell line HT1080.

AB - Two new abietane type diterpenoids, namely seco-helioscopinolide (1) and 3β,7β-dihydroxy-ent-abieta-8,13-diene-12,16-olide (2) were isolated from the aerial parts of Euphorbia formosana Hayata together with helioscopinolide A (3), helioscopinolide B (4), helioscopinolide C (5) and ent-(5β,8α,9β,10α,12α)-12-hydroxyatis-16-ene-3, 14-dione (6). The structures of compounds 1-6 were elucidated by analyzing their spectroscopic data and comparison with the literature. Further biological tests by gelatin zymographic analysis revealed that 3-5 significantly up-regulated the expressions and activation of MMP-2 and -9 in human fibrosarcoma cell line HT1080.

KW - Abietane diterpene

KW - Euphorbia formosana

KW - HT-1080

KW - MMP-2, -9

UR - http://www.scopus.com/inward/record.url?scp=84863142824&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84863142824&partnerID=8YFLogxK

U2 - 10.3390/molecules17022082

DO - 10.3390/molecules17022082

M3 - Article

C2 - 22354186

AN - SCOPUS:84863142824

VL - 17

SP - 2082

EP - 2090

JO - Molecules

JF - Molecules

SN - 1420-3049

IS - 2

ER -