Purpose: To report a serious complication following intravitreal triamcinolone acetonide injection. Methods: Observational case report. Results: In 2 patients, secondary intractable severe ocular hypertension occurred 2 months after a single 4-mg intravitreal injection of triamcinolone acetonide for macular edema. Both patients required trabeculectomy intervention to control intraocular pressure (IOP). Conclusion: We highlight the occurrence of intractable high IOP elevation as a serious complication 2 months after intravitreal triamcinolone ace- tonide. Cautious monitoring of IOP for several months after this therapy is recommended. The risks of this potentially devastating complication need to be weighed against the benefits of intravitreal triamcinolone in the individual patient.
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