摘要

Background and Purpose-: Reflux esophagitis (RE) is the most common manifestation of gastro-esophageal reflux disease with esophageal injury. To the best of our knowledge, there has been no specific study to evaluate the risk of stroke after diagnosis of RE in young adults. This study aims to evaluate the risk of stroke among RE patients aged 18 to 50 years during a 1-year period after diagnosis of RE compared to a cohort of non-RE patients during the same period. Methods-: This study used the Taiwan Longitudinal Health Insurance Database 2005. A total of 2340 RE patients were included as the study cohort and 11 700 non-RE patients were included as the comparison cohort. Each patient was individually tracked for 1 year from the index ambulatory visit to identify those in whom stroke developed. Results-: Out of the sample of 14 040 patients, 78 patients (0.56%) had strokes develop during the 1-year follow-up period: 22 from the study cohort (0.94% of the RE patients) and 56 from the comparison cohort (0.48% of patients without RE). Patients with RE were 1.68-times more likely to have strokes develop (95% confidence interval, 1.03-2.76) than patients in the comparison cohort during the follow-up period after adjusting for patients' medical comorbidities, such as hypertension, diabetes, coronary heart disease, renal disease, heart failure, and hyperlipidemia, as well as their demographic differences, such as the level of urbanization of their communities, monthly income, and geographical location. Conclusions-: We conclude that RE is associated with an increased risk of subsequent stroke in young adults.
原文英語
頁(從 - 到)2033-2037
頁數5
期刊Stroke
41
發行號9
DOIs
出版狀態已發佈 - 九月 2010

指紋

Peptic Esophagitis
Young Adult
Stroke
Population
Esophagitis
Cohort Studies
Esophageal Diseases
Urbanization
Health Insurance
Gastroesophageal Reflux
Hyperlipidemias
Taiwan
Coronary Disease
Comorbidity
Heart Failure

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine
  • Clinical Neurology
  • Advanced and Specialised Nursing
  • Medicine(all)

引用此文

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title = "Reflux esophagitis and the risk of stroke in young adults: A 1-year population-based follow-up study",
abstract = "Background and Purpose-: Reflux esophagitis (RE) is the most common manifestation of gastro-esophageal reflux disease with esophageal injury. To the best of our knowledge, there has been no specific study to evaluate the risk of stroke after diagnosis of RE in young adults. This study aims to evaluate the risk of stroke among RE patients aged 18 to 50 years during a 1-year period after diagnosis of RE compared to a cohort of non-RE patients during the same period. Methods-: This study used the Taiwan Longitudinal Health Insurance Database 2005. A total of 2340 RE patients were included as the study cohort and 11 700 non-RE patients were included as the comparison cohort. Each patient was individually tracked for 1 year from the index ambulatory visit to identify those in whom stroke developed. Results-: Out of the sample of 14 040 patients, 78 patients (0.56{\%}) had strokes develop during the 1-year follow-up period: 22 from the study cohort (0.94{\%} of the RE patients) and 56 from the comparison cohort (0.48{\%} of patients without RE). Patients with RE were 1.68-times more likely to have strokes develop (95{\%} confidence interval, 1.03-2.76) than patients in the comparison cohort during the follow-up period after adjusting for patients' medical comorbidities, such as hypertension, diabetes, coronary heart disease, renal disease, heart failure, and hyperlipidemia, as well as their demographic differences, such as the level of urbanization of their communities, monthly income, and geographical location. Conclusions-: We conclude that RE is associated with an increased risk of subsequent stroke in young adults.",
keywords = "esophagitis, reflux, stroke, young",
author = "Jau-Jiuan Sheu and Jiunn-Horng Kang and Lou, {Horng Yuan} and Herng-Ching Lin",
year = "2010",
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doi = "10.1161/STROKEAHA.110.588558",
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pages = "2033--2037",
journal = "Stroke",
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T1 - Reflux esophagitis and the risk of stroke in young adults

T2 - A 1-year population-based follow-up study

AU - Sheu, Jau-Jiuan

AU - Kang, Jiunn-Horng

AU - Lou, Horng Yuan

AU - Lin, Herng-Ching

PY - 2010/9

Y1 - 2010/9

N2 - Background and Purpose-: Reflux esophagitis (RE) is the most common manifestation of gastro-esophageal reflux disease with esophageal injury. To the best of our knowledge, there has been no specific study to evaluate the risk of stroke after diagnosis of RE in young adults. This study aims to evaluate the risk of stroke among RE patients aged 18 to 50 years during a 1-year period after diagnosis of RE compared to a cohort of non-RE patients during the same period. Methods-: This study used the Taiwan Longitudinal Health Insurance Database 2005. A total of 2340 RE patients were included as the study cohort and 11 700 non-RE patients were included as the comparison cohort. Each patient was individually tracked for 1 year from the index ambulatory visit to identify those in whom stroke developed. Results-: Out of the sample of 14 040 patients, 78 patients (0.56%) had strokes develop during the 1-year follow-up period: 22 from the study cohort (0.94% of the RE patients) and 56 from the comparison cohort (0.48% of patients without RE). Patients with RE were 1.68-times more likely to have strokes develop (95% confidence interval, 1.03-2.76) than patients in the comparison cohort during the follow-up period after adjusting for patients' medical comorbidities, such as hypertension, diabetes, coronary heart disease, renal disease, heart failure, and hyperlipidemia, as well as their demographic differences, such as the level of urbanization of their communities, monthly income, and geographical location. Conclusions-: We conclude that RE is associated with an increased risk of subsequent stroke in young adults.

AB - Background and Purpose-: Reflux esophagitis (RE) is the most common manifestation of gastro-esophageal reflux disease with esophageal injury. To the best of our knowledge, there has been no specific study to evaluate the risk of stroke after diagnosis of RE in young adults. This study aims to evaluate the risk of stroke among RE patients aged 18 to 50 years during a 1-year period after diagnosis of RE compared to a cohort of non-RE patients during the same period. Methods-: This study used the Taiwan Longitudinal Health Insurance Database 2005. A total of 2340 RE patients were included as the study cohort and 11 700 non-RE patients were included as the comparison cohort. Each patient was individually tracked for 1 year from the index ambulatory visit to identify those in whom stroke developed. Results-: Out of the sample of 14 040 patients, 78 patients (0.56%) had strokes develop during the 1-year follow-up period: 22 from the study cohort (0.94% of the RE patients) and 56 from the comparison cohort (0.48% of patients without RE). Patients with RE were 1.68-times more likely to have strokes develop (95% confidence interval, 1.03-2.76) than patients in the comparison cohort during the follow-up period after adjusting for patients' medical comorbidities, such as hypertension, diabetes, coronary heart disease, renal disease, heart failure, and hyperlipidemia, as well as their demographic differences, such as the level of urbanization of their communities, monthly income, and geographical location. Conclusions-: We conclude that RE is associated with an increased risk of subsequent stroke in young adults.

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