Reduced stimulating effect on one-way mixed lymphocyte culture by parturient's and neonatal cord blood cells.

J. J. Jiang, C. C. Hsu, H. N. Ho, T. Y. Lee

研究成果: 雜誌貢獻文章同行評審

摘要

One-way mixed lymphocyte culture (MLC), using the peripheral blood T, B cells and monocytes of 16 unmarried women who were never pregnant (i.e. nulligravidas) and 18 parturients, and the umbilical venous blood T, B cells and monocytes of 18 newborns as stimulating cells, were used to react with the peripheral mononuclear cells of a type "O" blood of a 29-year-old healthy man. We demonstrated that the stimulating effects were much lower in the parturients and the newborns than in the unmarried nulligravidas. The stimulating indices were significantly different, especially in the B cells. Mean stimulation index was 4.843 in unmarried nulligravidas, 1.249 in parturients and 1.284 in newborns. Our results seem to suggest that pregnancy produces some alternations on both the maternal and the fetal cells, making the maternal and the fetal immune systems fail to recognize each other.
原文英語
頁(從 - 到)474-477
頁數4
期刊Taiwan yi xue hui za zhi. Journal of the Formosan Medical Association
88
發行號5
出版狀態已發佈 - 五月 1 1989
對外發佈Yes

ASJC Scopus subject areas

  • Medicine(all)

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