Reduced expression of tocopherol-associated protein (TAP/Sec14L2) in human breast cancer.

X. Wang, Jing Ni, Chen Long Hsu, Sharlin Johnykutty, Ping Tang, Yuan Soon Ho, Chia Hwa Lee, Shuyuang Yeh

研究成果: 雜誌貢獻文章同行評審

摘要

We show that TAP/Sec14L2 had a high expression in normal/benign breast, prostate, and liver tissues as compared to lung, colon, and kidney. Its expression was downregulated in breast cancer cell lines shown by quantitative-PCR. Further, 57% of 141 human invasive breast carcinomas had no or markedly reduced TAP/Sec14L2 expression by immunohistochemical staining, and the rate increased to 80% in high grade invasive carcinomas (p <.01). This downregulation of TAP/Sec14L2 was also present in ductal carcinoma in situ (DCIS) associated with invasive carcinomas. These findings raise the possibility that TAP/Sec14L2 may serve as a tumor suppressor in breast carcinogenesis.
原文英語
頁(從 - 到)971-977
頁數7
期刊Cancer Investigation
27
發行號10
出版狀態已發佈 - 十二月 2009
對外發佈

ASJC Scopus subject areas

  • 癌症研究
  • 腫瘤科

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