Reduced activation and altered laterality in two neuroleptic-naive catatonic patients during a motor task in functional MRI

G. Northoff, D. F. Braus, A. Sartorius, D. Khoram-Sefat, M. Russ, J. Eckert, M. Herrig, A. Leschinger, B. Bogerts, F. A. Henn

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50 引文 斯高帕斯(Scopus)

摘要

Background. Catatonia, a symptom complex with motor, affective and cognitive symptoms seen in a variety of psychotic conditions and with organic disease, was examined using a motor task using functional magnetic resonance imaging (fMRI). Methods. Two acute catatonic patients and two age- and sex-matched healthy controls performed sequential finger opposition (SFO) after being medicated with 2 mg of lorazepam (i.v.). Functional magnetic resonance images were collected using a gradient echo pulse sequence (EPI). Results. Patients with catatonia showed reduced motor activation of the contralateral motor cortex during SFO of the right hand, ipsilateral activation was similar for patients and controls. There were no differences in the activation of the SMA. During left hand activation the right-handed catatonic patients showed more activation in the ipsilateral cortex, a reversal from the normal pattern of activation in which the contralateral side shows four to five times more activation than the ipsilateral side. Conclusions. In catatonic patients there is a decreased activation in motor cortex during a motor task compared to matched medicated healthy controls. In addition activation of the non-dominant side, left-handed activity in right-handed patients, results in a total reversal of the normal pattern of lateral activation suggesting a disturbance in hemispheric localization of activity during a catatonic state.
原文英語
頁(從 - 到)997-1002
頁數6
期刊Psychological Medicine
29
發行號4
DOIs
出版狀態已發佈 - 1999

ASJC Scopus subject areas

  • 精神病學和心理健康
  • 心理學(全部)
  • 臨床心理學

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