Recurrent bacteremia caused by the Acinetobacter calcoaceticus- Acinetobacter baumannii complex

Chih Cheng Lai, Han Lin Hsu, Che Kim Tan, Hsih Yeh Tsai, Aristine Cheng, Chia Ying Liu, Yu Tsung Huang, Chun Hsing Liao, Wang Huei Sheng, Po Ren Hsueh

研究成果: 雜誌貢獻文章

14 引文 (Scopus)

摘要

This study investigated the clinical and microbiological characteristics of patients with recurrent bacteremia caused by the Acinetobacter calcoaceticus-Acinetobacter baumannii (ACB) complex at a medical center. All ACB complex isolates associated with recurrent bacteremia were identified to the genomic species level using a 16S-23S rRNA gene intergenic spacer sequence-based method. Genotypes were determined by the random amplified polymorphic DNA patterns generated by arbitrarily primed PCR and by pulsotypes generated by pulsed-field gel electrophoresis. Relapse of infection was defined as when the genotype of the recurrent isolate was identical to that of the original infecting strain. Reinfection was defined as when the genospecies or genotype of the recurrent isolate differed from that of the original isolate. From 2006 to 2008, 446 patients had ACB complex bacteremia and 25 (5.6%) had recurrent bacteremia caused by the ACB complex. Among the 25 patients, 12 (48%) had relapse of bacteremia caused by A. nosocomialis (n = 7) or A. baumannii (n = 5). Among the 13 patients with reinfection, 5 (38.5%) had reinfection caused by different genospecies of the ACB complex. Most of the patients were immunocompromised, and most of the infection foci were catheter-related bloodstream infections. The overall in-hospital mortality rate was 33.3%. A. baumannii isolates had lower antimicrobial susceptibility rates than A. nosocomialis and A. pittii isolates. In conclusion, relapse of ACB complex bacteremia can develop in immunocompromised patients, especially those with central venous catheters. Molecular methods to identify the ACB complex to the genospecies level are essential for differentiating between reinfection and relapse of bacteremia caused by the ACB complex.

原文英語
頁(從 - 到)2982-2986
頁數5
期刊Journal of Clinical Microbiology
50
發行號9
DOIs
出版狀態已發佈 - 九月 1 2012

指紋

Acinetobacter calcoaceticus
Acinetobacter baumannii
Bacteremia
Recurrence
Genotype
Immunocompromised Host
Catheter-Related Infections
Intergenic DNA
Central Venous Catheters
Pulsed Field Gel Electrophoresis
Hospital Mortality
Infection
rRNA Genes

ASJC Scopus subject areas

  • Microbiology (medical)

引用此文

Recurrent bacteremia caused by the Acinetobacter calcoaceticus- Acinetobacter baumannii complex. / Lai, Chih Cheng; Hsu, Han Lin; Tan, Che Kim; Tsai, Hsih Yeh; Cheng, Aristine; Liu, Chia Ying; Huang, Yu Tsung; Liao, Chun Hsing; Sheng, Wang Huei; Hsueh, Po Ren.

於: Journal of Clinical Microbiology, 卷 50, 編號 9, 01.09.2012, p. 2982-2986.

研究成果: 雜誌貢獻文章

Lai, CC, Hsu, HL, Tan, CK, Tsai, HY, Cheng, A, Liu, CY, Huang, YT, Liao, CH, Sheng, WH & Hsueh, PR 2012, 'Recurrent bacteremia caused by the Acinetobacter calcoaceticus- Acinetobacter baumannii complex', Journal of Clinical Microbiology, 卷 50, 編號 9, 頁 2982-2986. https://doi.org/10.1128/JCM.01194-12
Lai, Chih Cheng ; Hsu, Han Lin ; Tan, Che Kim ; Tsai, Hsih Yeh ; Cheng, Aristine ; Liu, Chia Ying ; Huang, Yu Tsung ; Liao, Chun Hsing ; Sheng, Wang Huei ; Hsueh, Po Ren. / Recurrent bacteremia caused by the Acinetobacter calcoaceticus- Acinetobacter baumannii complex. 於: Journal of Clinical Microbiology. 2012 ; 卷 50, 編號 9. 頁 2982-2986.
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abstract = "This study investigated the clinical and microbiological characteristics of patients with recurrent bacteremia caused by the Acinetobacter calcoaceticus-Acinetobacter baumannii (ACB) complex at a medical center. All ACB complex isolates associated with recurrent bacteremia were identified to the genomic species level using a 16S-23S rRNA gene intergenic spacer sequence-based method. Genotypes were determined by the random amplified polymorphic DNA patterns generated by arbitrarily primed PCR and by pulsotypes generated by pulsed-field gel electrophoresis. Relapse of infection was defined as when the genotype of the recurrent isolate was identical to that of the original infecting strain. Reinfection was defined as when the genospecies or genotype of the recurrent isolate differed from that of the original isolate. From 2006 to 2008, 446 patients had ACB complex bacteremia and 25 (5.6{\%}) had recurrent bacteremia caused by the ACB complex. Among the 25 patients, 12 (48{\%}) had relapse of bacteremia caused by A. nosocomialis (n = 7) or A. baumannii (n = 5). Among the 13 patients with reinfection, 5 (38.5{\%}) had reinfection caused by different genospecies of the ACB complex. Most of the patients were immunocompromised, and most of the infection foci were catheter-related bloodstream infections. The overall in-hospital mortality rate was 33.3{\%}. A. baumannii isolates had lower antimicrobial susceptibility rates than A. nosocomialis and A. pittii isolates. In conclusion, relapse of ACB complex bacteremia can develop in immunocompromised patients, especially those with central venous catheters. Molecular methods to identify the ACB complex to the genospecies level are essential for differentiating between reinfection and relapse of bacteremia caused by the ACB complex.",
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AU - Cheng, Aristine

AU - Liu, Chia Ying

AU - Huang, Yu Tsung

AU - Liao, Chun Hsing

AU - Sheng, Wang Huei

AU - Hsueh, Po Ren

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N2 - This study investigated the clinical and microbiological characteristics of patients with recurrent bacteremia caused by the Acinetobacter calcoaceticus-Acinetobacter baumannii (ACB) complex at a medical center. All ACB complex isolates associated with recurrent bacteremia were identified to the genomic species level using a 16S-23S rRNA gene intergenic spacer sequence-based method. Genotypes were determined by the random amplified polymorphic DNA patterns generated by arbitrarily primed PCR and by pulsotypes generated by pulsed-field gel electrophoresis. Relapse of infection was defined as when the genotype of the recurrent isolate was identical to that of the original infecting strain. Reinfection was defined as when the genospecies or genotype of the recurrent isolate differed from that of the original isolate. From 2006 to 2008, 446 patients had ACB complex bacteremia and 25 (5.6%) had recurrent bacteremia caused by the ACB complex. Among the 25 patients, 12 (48%) had relapse of bacteremia caused by A. nosocomialis (n = 7) or A. baumannii (n = 5). Among the 13 patients with reinfection, 5 (38.5%) had reinfection caused by different genospecies of the ACB complex. Most of the patients were immunocompromised, and most of the infection foci were catheter-related bloodstream infections. The overall in-hospital mortality rate was 33.3%. A. baumannii isolates had lower antimicrobial susceptibility rates than A. nosocomialis and A. pittii isolates. In conclusion, relapse of ACB complex bacteremia can develop in immunocompromised patients, especially those with central venous catheters. Molecular methods to identify the ACB complex to the genospecies level are essential for differentiating between reinfection and relapse of bacteremia caused by the ACB complex.

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