摘要

Background: Recurrent aphthous stomatitis (RAS) is considered a prophase symptom in patients with specific cancers. This study assessed the association between RAS and subsequent onset of cancer based on a nationwide population-based database in Taiwan. Materials and Methods: We selected study participants from the National Health Insurance Research Database from January 2000 to December 2008. Patients in the non-RAS cohort were matched to case study patients at a 1:1 ratio through frequency matching. All participants were followed up for at least 5 years, and those who received cancer diagnoses during follow-up were identified. Results: Among 52 307 patients with and 52 304 patients without RAS, the combined hazard ratio (HR) of all subsequent cancer cases was 1.3 (95% confidence interval [CI]: 1.25-1.35, P = 0). RAS diagnosis was associated with risk for cancers of the head and neck (aHR = 2, 95% CI: 1.8-2.3), colon (aHR = 1.2, 95% CI: 1.1-1.4), liver (aHR = 1.1, 95% CI: 1-1.3), pancreas (aHR = 1.4, 95% CI: 1.1-1.7), skin (aHR = 1.4, 95% CI: 1.2-1.7), breast (aHR = 1.2, 95% CI: 1.1-1.4), and prostate (aHR = 1.5, 95% CI: 1.3-1.8), as well as hematologic cancers (aHR = 1.6, 95% CI: 1.3-1.9). A higher risk was observed for male patients (aHR = 1.35, 95% CI: 1.28-1.42) than for female patients (aHR = 1.25, 95% CI: 1.18-1.31) with RAS. Conclusions: RAS was associated with specific cancers. Susceptible RAS patients should be screened for specific cancers.
原文英語
期刊Cancer Medicine
DOIs
出版狀態接受/付印 - 一月 1 2018

指紋

Case-Control Studies
Confidence Intervals
Neoplasms
Sutton disease 2
Databases
Aphthous Stomatitis
Prophase
National Health Programs
Head and Neck Neoplasms
Taiwan
Prostate
Pancreas
Colon
Breast
Skin
Liver
Research

ASJC Scopus subject areas

  • Oncology
  • Radiology Nuclear Medicine and imaging
  • Cancer Research

引用此文

Recurrent aphthous stomatitis may be a precursor or risk factor for specific cancers : A case-control frequency-matched study. / Qin, Lei; Kao, Yi Wei; Lin, Yueh Lung; Peng, Bou Yue; Deng, Win Ping; Chen, Tsung Ming; Lin, Kuan Chou; Yuan, Kevin Sheng Po; Wu, Alexander T.H.; Shia, Ben Chang; Wu, Szu Yuan.

於: Cancer Medicine, 01.01.2018.

研究成果: 雜誌貢獻文章

@article{83c4ed023734438fa2e8b1d49b46f121,
title = "Recurrent aphthous stomatitis may be a precursor or risk factor for specific cancers: A case-control frequency-matched study",
abstract = "Background: Recurrent aphthous stomatitis (RAS) is considered a prophase symptom in patients with specific cancers. This study assessed the association between RAS and subsequent onset of cancer based on a nationwide population-based database in Taiwan. Materials and Methods: We selected study participants from the National Health Insurance Research Database from January 2000 to December 2008. Patients in the non-RAS cohort were matched to case study patients at a 1:1 ratio through frequency matching. All participants were followed up for at least 5 years, and those who received cancer diagnoses during follow-up were identified. Results: Among 52 307 patients with and 52 304 patients without RAS, the combined hazard ratio (HR) of all subsequent cancer cases was 1.3 (95{\%} confidence interval [CI]: 1.25-1.35, P = 0). RAS diagnosis was associated with risk for cancers of the head and neck (aHR = 2, 95{\%} CI: 1.8-2.3), colon (aHR = 1.2, 95{\%} CI: 1.1-1.4), liver (aHR = 1.1, 95{\%} CI: 1-1.3), pancreas (aHR = 1.4, 95{\%} CI: 1.1-1.7), skin (aHR = 1.4, 95{\%} CI: 1.2-1.7), breast (aHR = 1.2, 95{\%} CI: 1.1-1.4), and prostate (aHR = 1.5, 95{\%} CI: 1.3-1.8), as well as hematologic cancers (aHR = 1.6, 95{\%} CI: 1.3-1.9). A higher risk was observed for male patients (aHR = 1.35, 95{\%} CI: 1.28-1.42) than for female patients (aHR = 1.25, 95{\%} CI: 1.18-1.31) with RAS. Conclusions: RAS was associated with specific cancers. Susceptible RAS patients should be screened for specific cancers.",
keywords = "Cancer, Case-control, Gender, Recurrent aphthous stomatitis, Risk factor",
author = "Lei Qin and Kao, {Yi Wei} and Lin, {Yueh Lung} and Peng, {Bou Yue} and Deng, {Win Ping} and Chen, {Tsung Ming} and Lin, {Kuan Chou} and Yuan, {Kevin Sheng Po} and Wu, {Alexander T.H.} and Shia, {Ben Chang} and Wu, {Szu Yuan}",
year = "2018",
month = "1",
day = "1",
doi = "10.1002/cam4.1685",
language = "English",
journal = "Cancer Medicine",
issn = "2045-7634",
publisher = "John Wiley and Sons Ltd",

}

TY - JOUR

T1 - Recurrent aphthous stomatitis may be a precursor or risk factor for specific cancers

T2 - A case-control frequency-matched study

AU - Qin, Lei

AU - Kao, Yi Wei

AU - Lin, Yueh Lung

AU - Peng, Bou Yue

AU - Deng, Win Ping

AU - Chen, Tsung Ming

AU - Lin, Kuan Chou

AU - Yuan, Kevin Sheng Po

AU - Wu, Alexander T.H.

AU - Shia, Ben Chang

AU - Wu, Szu Yuan

PY - 2018/1/1

Y1 - 2018/1/1

N2 - Background: Recurrent aphthous stomatitis (RAS) is considered a prophase symptom in patients with specific cancers. This study assessed the association between RAS and subsequent onset of cancer based on a nationwide population-based database in Taiwan. Materials and Methods: We selected study participants from the National Health Insurance Research Database from January 2000 to December 2008. Patients in the non-RAS cohort were matched to case study patients at a 1:1 ratio through frequency matching. All participants were followed up for at least 5 years, and those who received cancer diagnoses during follow-up were identified. Results: Among 52 307 patients with and 52 304 patients without RAS, the combined hazard ratio (HR) of all subsequent cancer cases was 1.3 (95% confidence interval [CI]: 1.25-1.35, P = 0). RAS diagnosis was associated with risk for cancers of the head and neck (aHR = 2, 95% CI: 1.8-2.3), colon (aHR = 1.2, 95% CI: 1.1-1.4), liver (aHR = 1.1, 95% CI: 1-1.3), pancreas (aHR = 1.4, 95% CI: 1.1-1.7), skin (aHR = 1.4, 95% CI: 1.2-1.7), breast (aHR = 1.2, 95% CI: 1.1-1.4), and prostate (aHR = 1.5, 95% CI: 1.3-1.8), as well as hematologic cancers (aHR = 1.6, 95% CI: 1.3-1.9). A higher risk was observed for male patients (aHR = 1.35, 95% CI: 1.28-1.42) than for female patients (aHR = 1.25, 95% CI: 1.18-1.31) with RAS. Conclusions: RAS was associated with specific cancers. Susceptible RAS patients should be screened for specific cancers.

AB - Background: Recurrent aphthous stomatitis (RAS) is considered a prophase symptom in patients with specific cancers. This study assessed the association between RAS and subsequent onset of cancer based on a nationwide population-based database in Taiwan. Materials and Methods: We selected study participants from the National Health Insurance Research Database from January 2000 to December 2008. Patients in the non-RAS cohort were matched to case study patients at a 1:1 ratio through frequency matching. All participants were followed up for at least 5 years, and those who received cancer diagnoses during follow-up were identified. Results: Among 52 307 patients with and 52 304 patients without RAS, the combined hazard ratio (HR) of all subsequent cancer cases was 1.3 (95% confidence interval [CI]: 1.25-1.35, P = 0). RAS diagnosis was associated with risk for cancers of the head and neck (aHR = 2, 95% CI: 1.8-2.3), colon (aHR = 1.2, 95% CI: 1.1-1.4), liver (aHR = 1.1, 95% CI: 1-1.3), pancreas (aHR = 1.4, 95% CI: 1.1-1.7), skin (aHR = 1.4, 95% CI: 1.2-1.7), breast (aHR = 1.2, 95% CI: 1.1-1.4), and prostate (aHR = 1.5, 95% CI: 1.3-1.8), as well as hematologic cancers (aHR = 1.6, 95% CI: 1.3-1.9). A higher risk was observed for male patients (aHR = 1.35, 95% CI: 1.28-1.42) than for female patients (aHR = 1.25, 95% CI: 1.18-1.31) with RAS. Conclusions: RAS was associated with specific cancers. Susceptible RAS patients should be screened for specific cancers.

KW - Cancer

KW - Case-control

KW - Gender

KW - Recurrent aphthous stomatitis

KW - Risk factor

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