Recovery of elevated atrial natriuretic peptide in pressure-overload right heart failure

Chia Ming Hsieh, Liang Shun Wang, Hans Joachim Schaefers, Shinichiro Miyoshi, Paulo F G Cardoso, Alexander Logan, Gregory Mishkel, Harry Rakowski, Joel D. Cooper

研究成果: 雜誌貢獻文章

4 引文 (Scopus)

摘要

Elevation of the plasma concentrations of immunoreactive atrial natriuretic peptide (ANP) was observed in canine chronic right heart failure (RHF) secondary to right ventricular (RV) pressure overload. Pressure overload on the right heart was gradually increased using an inflatable cuff. The interval between banding and the onset of RHF was 152 ± 52 days. Seventeen RHF dogs were produced and divided into Group I (n = 11) and Group II (n = 6). At the onset of RHF, Group I dogs were either sacrificed for study of the heart, or unbanded to allow recovery from RHF. The dogs in Group II were maintained in RHF for 3 additional months before being either sacrificed or unbanded. Following unbanding, the ANP level of Group I recovered from 108 ± 36 (n = 11) to 20 ± 6 pg/ml (n = 6) at 1 month and was maintained at 27 ± 7 pg/ml (baseline, 21 ± 5 pg/ml, n = 11) at 4 months. ANP levels of Group II declined from 165 ± 55 (n = 6) to 87 ± 2 pg/ml (n = 3) at 1 month and further decreased to 42 ± 14 pg/ml (n = 3) 4 months after unbanding. Thus, compared to Group I, Group II had a high ANP level before unbanding and a delay in recovery of the ANP levels despite normalization of the right atrial pressure (RAP). Four months after release of pressure overload, the right atrial hypertrophy persisted in the unbanded dogs; however, Group I unbanded dogs showed a better reversal of the right atrial hypertrophy than Group II unbanded dogs. We concluded that in chronic RHF, decrease of the elevated ANP levels depends on normalization of the right atrial pressure and persistent mild increase of ANP levels may correlate with the remaining hypertrophy of the right atrium.

原文英語
頁(從 - 到)304-308
頁數5
期刊Journal of Surgical Research
47
發行號4
DOIs
出版狀態已發佈 - 1989
對外發佈Yes

指紋

Atrial Natriuretic Factor
Heart Failure
Pressure
Dogs
Hypertrophy
Atrial Pressure
Ventricular Pressure
Heart Atria
Canidae

ASJC Scopus subject areas

  • Surgery

引用此文

Hsieh, C. M., Wang, L. S., Schaefers, H. J., Miyoshi, S., Cardoso, P. F. G., Logan, A., ... Cooper, J. D. (1989). Recovery of elevated atrial natriuretic peptide in pressure-overload right heart failure. Journal of Surgical Research, 47(4), 304-308. https://doi.org/10.1016/0022-4804(89)90139-X

Recovery of elevated atrial natriuretic peptide in pressure-overload right heart failure. / Hsieh, Chia Ming; Wang, Liang Shun; Schaefers, Hans Joachim; Miyoshi, Shinichiro; Cardoso, Paulo F G; Logan, Alexander; Mishkel, Gregory; Rakowski, Harry; Cooper, Joel D.

於: Journal of Surgical Research, 卷 47, 編號 4, 1989, p. 304-308.

研究成果: 雜誌貢獻文章

Hsieh, CM, Wang, LS, Schaefers, HJ, Miyoshi, S, Cardoso, PFG, Logan, A, Mishkel, G, Rakowski, H & Cooper, JD 1989, 'Recovery of elevated atrial natriuretic peptide in pressure-overload right heart failure', Journal of Surgical Research, 卷 47, 編號 4, 頁 304-308. https://doi.org/10.1016/0022-4804(89)90139-X
Hsieh, Chia Ming ; Wang, Liang Shun ; Schaefers, Hans Joachim ; Miyoshi, Shinichiro ; Cardoso, Paulo F G ; Logan, Alexander ; Mishkel, Gregory ; Rakowski, Harry ; Cooper, Joel D. / Recovery of elevated atrial natriuretic peptide in pressure-overload right heart failure. 於: Journal of Surgical Research. 1989 ; 卷 47, 編號 4. 頁 304-308.
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title = "Recovery of elevated atrial natriuretic peptide in pressure-overload right heart failure",
abstract = "Elevation of the plasma concentrations of immunoreactive atrial natriuretic peptide (ANP) was observed in canine chronic right heart failure (RHF) secondary to right ventricular (RV) pressure overload. Pressure overload on the right heart was gradually increased using an inflatable cuff. The interval between banding and the onset of RHF was 152 ± 52 days. Seventeen RHF dogs were produced and divided into Group I (n = 11) and Group II (n = 6). At the onset of RHF, Group I dogs were either sacrificed for study of the heart, or unbanded to allow recovery from RHF. The dogs in Group II were maintained in RHF for 3 additional months before being either sacrificed or unbanded. Following unbanding, the ANP level of Group I recovered from 108 ± 36 (n = 11) to 20 ± 6 pg/ml (n = 6) at 1 month and was maintained at 27 ± 7 pg/ml (baseline, 21 ± 5 pg/ml, n = 11) at 4 months. ANP levels of Group II declined from 165 ± 55 (n = 6) to 87 ± 2 pg/ml (n = 3) at 1 month and further decreased to 42 ± 14 pg/ml (n = 3) 4 months after unbanding. Thus, compared to Group I, Group II had a high ANP level before unbanding and a delay in recovery of the ANP levels despite normalization of the right atrial pressure (RAP). Four months after release of pressure overload, the right atrial hypertrophy persisted in the unbanded dogs; however, Group I unbanded dogs showed a better reversal of the right atrial hypertrophy than Group II unbanded dogs. We concluded that in chronic RHF, decrease of the elevated ANP levels depends on normalization of the right atrial pressure and persistent mild increase of ANP levels may correlate with the remaining hypertrophy of the right atrium.",
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AU - Hsieh, Chia Ming

AU - Wang, Liang Shun

AU - Schaefers, Hans Joachim

AU - Miyoshi, Shinichiro

AU - Cardoso, Paulo F G

AU - Logan, Alexander

AU - Mishkel, Gregory

AU - Rakowski, Harry

AU - Cooper, Joel D.

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N2 - Elevation of the plasma concentrations of immunoreactive atrial natriuretic peptide (ANP) was observed in canine chronic right heart failure (RHF) secondary to right ventricular (RV) pressure overload. Pressure overload on the right heart was gradually increased using an inflatable cuff. The interval between banding and the onset of RHF was 152 ± 52 days. Seventeen RHF dogs were produced and divided into Group I (n = 11) and Group II (n = 6). At the onset of RHF, Group I dogs were either sacrificed for study of the heart, or unbanded to allow recovery from RHF. The dogs in Group II were maintained in RHF for 3 additional months before being either sacrificed or unbanded. Following unbanding, the ANP level of Group I recovered from 108 ± 36 (n = 11) to 20 ± 6 pg/ml (n = 6) at 1 month and was maintained at 27 ± 7 pg/ml (baseline, 21 ± 5 pg/ml, n = 11) at 4 months. ANP levels of Group II declined from 165 ± 55 (n = 6) to 87 ± 2 pg/ml (n = 3) at 1 month and further decreased to 42 ± 14 pg/ml (n = 3) 4 months after unbanding. Thus, compared to Group I, Group II had a high ANP level before unbanding and a delay in recovery of the ANP levels despite normalization of the right atrial pressure (RAP). Four months after release of pressure overload, the right atrial hypertrophy persisted in the unbanded dogs; however, Group I unbanded dogs showed a better reversal of the right atrial hypertrophy than Group II unbanded dogs. We concluded that in chronic RHF, decrease of the elevated ANP levels depends on normalization of the right atrial pressure and persistent mild increase of ANP levels may correlate with the remaining hypertrophy of the right atrium.

AB - Elevation of the plasma concentrations of immunoreactive atrial natriuretic peptide (ANP) was observed in canine chronic right heart failure (RHF) secondary to right ventricular (RV) pressure overload. Pressure overload on the right heart was gradually increased using an inflatable cuff. The interval between banding and the onset of RHF was 152 ± 52 days. Seventeen RHF dogs were produced and divided into Group I (n = 11) and Group II (n = 6). At the onset of RHF, Group I dogs were either sacrificed for study of the heart, or unbanded to allow recovery from RHF. The dogs in Group II were maintained in RHF for 3 additional months before being either sacrificed or unbanded. Following unbanding, the ANP level of Group I recovered from 108 ± 36 (n = 11) to 20 ± 6 pg/ml (n = 6) at 1 month and was maintained at 27 ± 7 pg/ml (baseline, 21 ± 5 pg/ml, n = 11) at 4 months. ANP levels of Group II declined from 165 ± 55 (n = 6) to 87 ± 2 pg/ml (n = 3) at 1 month and further decreased to 42 ± 14 pg/ml (n = 3) 4 months after unbanding. Thus, compared to Group I, Group II had a high ANP level before unbanding and a delay in recovery of the ANP levels despite normalization of the right atrial pressure (RAP). Four months after release of pressure overload, the right atrial hypertrophy persisted in the unbanded dogs; however, Group I unbanded dogs showed a better reversal of the right atrial hypertrophy than Group II unbanded dogs. We concluded that in chronic RHF, decrease of the elevated ANP levels depends on normalization of the right atrial pressure and persistent mild increase of ANP levels may correlate with the remaining hypertrophy of the right atrium.

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