Recovering Individual Genomes from Metagenomes Using MaxBin 2.0

Yu Wei Wu, Steven W. Singer

研究成果: 雜誌貢獻文章同行評審

2 引文 斯高帕斯(Scopus)

摘要

It is critical to identify individual genomes from microbiomic samples in order to carry out analysis of the microbes. Methods based on existing databases, however, may have limited capabilities in elucidating and quantifying the microbes due to the largely unidentified microbial species in natural or human-associated environments. We thus developed a database-free method, MaxBin 2.0, to aid in the process of recovering microbial genomes from metagenomes in a de novo manner. The recovery of individual genomes allows analysis of the microbiome in terms of a collection of microbial genomes so that one can understand the functional roles of each species. The data of individual microbes may then be analyzed collectively to untangle the interactions between different microbial organisms. By reporting the genome abundance information for co-assembled metagenomes, one may also identify which microorganisms dominate the microbiome and which species may co-occur from the MaxBin 2.0 results.

原文英語
文章編號e128
期刊Current Protocols
1
發行號5
DOIs
出版狀態已發佈 - 5月 2021

ASJC Scopus subject areas

  • 生物化學、遺傳與分子生物學 (全部)
  • 藥理學、毒理學和藥劑學 (全部)
  • 神經科學 (全部)
  • 免疫學與微生物學 (全部)
  • 健康資訊學
  • 醫學實驗室技術
  • 醫藥 (全部)

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