Recombinant viral capsid protein VP1 suppresses migration and invasion of human cervical cancer by modulating phosphorylated prohibitin in lipid rafts

Ching Feng Chiu, Jei Ming Peng, Shao Wen Hung, Chi Ming Liang, Shu Mei Liang

研究成果: 雜誌貢獻文章

10 引文 斯高帕斯(Scopus)

摘要

Recombinant capsid protein VP1 (rVP1) of foot-and-mouth disease virus inhibits invasion/metastasis of cancer cells. Here we studied its mechanism of action on human cervical cancer cells. The inhibition of cell invasion by rVP1 was accompanied with reduction in phosphatidylinositol (3,4,5)-triphosphate (PIP3), phospho-Akt S473, phosphorylated prohibitin (phospho-PHB) T258 in lipid rafts, dissociation of phospho-PHB T258 with Raf-1 and the inactivation of Raf-1/ERK. Addition of PIP3 or overexpression of constitutively active Akt and raft-anchored PHB T258 but not PHB T258I mutant protein reversed the inhibitory effects of rVP1. rVP1 inhibited cervical tumor growth and metastasis, and prolonged survival in xenograft mouse models. These results suggest that rVP1 inhibits cancer metastasis via de-phosphorylation of Akt and PHB T258 in lipid rafts to downregulate Raf/ERK signaling.
原文英語
頁(從 - 到)205-214
頁數10
期刊Cancer Letters
320
發行號2
DOIs
出版狀態已發佈 - 七月 28 2012
對外發佈Yes

ASJC Scopus subject areas

  • Oncology
  • Cancer Research

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