Receptor for advanced glycation endproducts mediates neutrophil migration across intestinal epithelium

Ke Zen, Celia X.J. Chen, Yi Tien Chen, Rosemarie Wilton, Yuan Liu

研究成果: 雜誌貢獻文章同行評審

59 引文 斯高帕斯(Scopus)

摘要

Receptor for advanced glycation endproducts (RAGE) is an Ig superfamily cell surface receptor that interacts with a diverse array of ligands associated with inflammatory responses. In this study, we provide evidence demonstrating that RAGE is involved in inflammatory responses in the intestines. We showed that RAGE is expressed in intestinal epithelial cells, primarily concentrated at the lateral membranes close to the apical cell junction complexes. Although RAGE expression was low in epithelium under normal conditions, this protein was up-regulated after treatment with the inflammatory cytokines IFN-γ and/or TNF-α. RAGE expression was also elevated in colon tissue samples from patients with inflammatory bowel diseases. Using in vitro transmigration assays, we found that RAGE mediates neutrophil (polymorphonuclear leukocytes (PMN)) adhesion to, and subsequent migration across, intestinal epithelial monolayers. This activity appears to be mediated by the binding of RAGE to the PMN-specific β2 integrin CD11b/CD18. Thus, these results provide a novel mechanism for the regulation of PMN transepithelial migration and may suggest a new therapeutic target for intestinal inflammation.
原文英語
頁(從 - 到)2483-2490
頁數8
期刊Journal of Immunology
178
發行號4
DOIs
出版狀態已發佈 - 2月 15 2007
對外發佈

ASJC Scopus subject areas

  • 免疫學

指紋

深入研究「Receptor for advanced glycation endproducts mediates neutrophil migration across intestinal epithelium」主題。共同形成了獨特的指紋。

引用此