Re-emergence of meningococcal disease in Taiwan: Circulation of domestic clones of Neisseria meningitidis in the 2001 outbreak

P. R. Hsueh, L. J. Teng, T. Y. Lin, K. T. Chen, H. M. Hsu, S. J. Twu, S. W. Ho, K. T. Luh

研究成果: 雜誌貢獻文章

10 引文 (Scopus)

摘要

The annual incidence of meningococcal disease (meningitis and septicaemia) in Taiwan was 0.94/105 population in 1953. It then declined to below 0.001 from 1980 to 1987, and re-emerged in 2000 with a rate of 0.07/105 population. In 2001 there was a further increase in incidence (43 cases, 0.19/105). Of 43 isolates of Neisseria meningitidis available for this study, including 41 from patients treated in 2001, three (7.0%) were penicillin insensitive (MIC ≥0.12 μg/ml), though all were β-lactamase negative; 16 (37.2%) were resistant to trimethoprim - sulphamethoxazole (MIC ≥4/76 μg/ml). Serogrouping and genotype analysis revealed nine domestic clones. None of the 43 patients had any relationship (travel or contact history) with the 2000 or 2001 Hajj pilgrimage. Epidemiological information and typing results suggested wide dissemination of a limited number of domestic clones of N. meningitidis, manifesting as serogroups W-135, B and Y. Two clones of serogroup W-135 involved in the outbreak were genetically distinct from the 2000 or 2001 Hajj-related W-135 clone.
原文英語
頁(從 - 到)637-645
頁數9
期刊Epidemiology and Infection
132
發行號4
DOIs
出版狀態已發佈 - 八月 2004
對外發佈Yes

指紋

Neisseria meningitidis
Taiwan
Disease Outbreaks
Clone Cells
Meningococcal Meningitis
Sulfamethoxazole
Trimethoprim
Incidence
Penicillins
Population
Sepsis
History
Genotype
Serogroup

ASJC Scopus subject areas

  • Epidemiology
  • Infectious Diseases

引用此文

Re-emergence of meningococcal disease in Taiwan : Circulation of domestic clones of Neisseria meningitidis in the 2001 outbreak. / Hsueh, P. R.; Teng, L. J.; Lin, T. Y.; Chen, K. T.; Hsu, H. M.; Twu, S. J.; Ho, S. W.; Luh, K. T.

於: Epidemiology and Infection, 卷 132, 編號 4, 08.2004, p. 637-645.

研究成果: 雜誌貢獻文章

Hsueh, P. R. ; Teng, L. J. ; Lin, T. Y. ; Chen, K. T. ; Hsu, H. M. ; Twu, S. J. ; Ho, S. W. ; Luh, K. T. / Re-emergence of meningococcal disease in Taiwan : Circulation of domestic clones of Neisseria meningitidis in the 2001 outbreak. 於: Epidemiology and Infection. 2004 ; 卷 132, 編號 4. 頁 637-645.
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