Ratio of dietary ω-3 and ω-6 fatty acids—independent determinants of muscle mass—in hemodialysis patients with diabetes

Te Chih Wong, Yu Tong Chen, Pei Yu Wu, Tzen Wen Chen, Hsi Hsien Chen, Tso Hsiao Chen, Yung Ho Hsu, Shwu Huey Yang

研究成果: 雜誌貢獻文章同行評審

4 引文 斯高帕斯(Scopus)

摘要

Objective: n-3 and n-6 polyunsaturated fatty acids (PUFAs) are essential nutrients in the human diet and possibly affect muscle mass. We evaluated the association between the dietary ratios of n-3 and n-6 PUFAs and muscle mass, indicated as skeletal muscle mass (SMM) and appendicular skeletal muscle mass (ASM), in patients with diabetes undergoing hemodialysis (HD). Methods: In this cross-sectional study, data on 69 patients with diabetes who underwent standard HD therapy were analyzed. For estimating muscle mass, anthropometric and bioelectrical impedance analyses were conducted following dialysis. In addition, routine laboratory and 3-d dietary data were obtained. The adequate intake (AI) cut-off for n-3 PUFAs was 1.6 g/d and 1.1 g/d for male and female patients, respectively. Results: The average age of the participants was 63.0 ± 10.4 y. The mean ratios of n-3/n-6 PUFA intake, n-6/n-3 PUFA intake, SMM, and ASM of the patients were 0.13 ± 0.07, 9.4 ± 6.4, 24.6 ± 5.4 kg, and 18.3 ± 4.6 kg, respectively. Patients who had AI of n-3 PUFAs had significantly higher SMM and ASM than did their counterparts. Linear and stepwise multivariable adjustment analyses revealed that insulin resistance and the n-6/n-3 PUFA ratio were the independent deleterious determinants of ASM normalized to height in HD patients. Conclusions: Patients with AI of n-3 PUFAs had total-body SMM and ASM that were more appropriate. A higher dietary ratio of n-6/n-3 PUFAs was associated with reduced muscle mass in HD patients.
原文英語
頁(從 - 到)989-994
頁數6
期刊Nutrition
32
發行號9
DOIs
出版狀態已發佈 - 九月 1 2016

ASJC Scopus subject areas

  • Endocrinology, Diabetes and Metabolism
  • Nutrition and Dietetics

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