Rates of susceptibility of carbapenems, ceftobiprole, and colistin against clinically important bacteria collected from intensive care units in 2007

Results from the Surveillance of Multicenter Antimicrobial Resistance in Taiwan (SMART)

ShioShin Jean, Wen-Sen Lee, Kwok Woon Yu, Chun Hsing Liao, Chin-Wung Hsu, Feng Yi Chang, Wen Chien Ko, Ray-Jade Chen, Jiunn Jong Wu, Yen Hsu Chen, Yao Shen Chen, Jien Wei Liu, Min Chi Lu, Carlos Lam, Cheng Yi Liu, Po Ren Hsueh

研究成果: 雜誌貢獻文章

16 引文 (Scopus)

摘要

Background: Data on susceptibility to ceftobiprole and colistin, and the complete evolutionary trends of minimum inhibitory concentrations (MICs) of important carbapenem agents among important pathogens collected in intensive care units (ICUs) in Taiwan are lacking. Methods: We surveyed the MIC distribution patterns of ceftobiprole and colistin and susceptibility profiles of some important pathogens collected from patients hospitalized in intensive care units (ICUs) of major teaching hospitals throughout Taiwan in 2007. We also investigated the rates of nonsusceptibility to powerful carbapenems (imipenem, meropenem) among four important species of Enterobacteriaceae (Escherichia coli, Klebsiella pneumoniae, Enterobacter cloacae, and Proteus mirabilis) collected during the same period. MIC breakpoints recommended by the Clinical and Laboratory Standards Institute in 2014 were applied. Results: Colistin showed excellent invitro activity (susceptibility rate, 96%) against Acinetobacter baumannii isolates but moderate (73-77% susceptibility rate) activity against isolates of Pseudomonas aeruginosa and E. cloacae. The ceftobiprole MIC90 value was 4μg/mL for methicillin-resistant Staphylococcus aureus and 16μg/mL for P. aeruginosa. The phenotype of methicillin resistance did not markedly increase the MIC value of ceftobiprole among S. aureus isolates. Interestingly, the proportion of isolates that displayed nonsusceptibility to imipenem was significantly higher among P. mirabilis isolates than among isolates of the other three Enterobacteriaceae species, regardless of the production of extended-spectrum β-lactamase. Conclusion: Continuous monitoring of susceptibility profiles of ICU pathogens to important antibiotics is warranted to provide appropriate antimicrobial regimens against infections in the ICU.
原文英語
頁(從 - 到)969-976
期刊Journal of Microbiology, Immunology and Infection
49
發行號6
DOIs
出版狀態已發佈 - 十二月 1 2016

指紋

Colistin
Carbapenems
Microbial Sensitivity Tests
Taiwan
Intensive Care Units
Bacteria
Enterobacter cloacae
Proteus mirabilis
Imipenem
meropenem
Enterobacteriaceae
Pseudomonas aeruginosa
Acinetobacter baumannii
Methicillin Resistance
Klebsiella pneumoniae
Methicillin-Resistant Staphylococcus aureus
Teaching Hospitals
Staphylococcus aureus
Escherichia coli
Anti-Bacterial Agents

ASJC Scopus subject areas

  • Microbiology (medical)
  • Immunology and Allergy
  • Immunology and Microbiology(all)
  • Infectious Diseases

引用此文

Rates of susceptibility of carbapenems, ceftobiprole, and colistin against clinically important bacteria collected from intensive care units in 2007 : Results from the Surveillance of Multicenter Antimicrobial Resistance in Taiwan (SMART). / Jean, ShioShin; Lee, Wen-Sen; Yu, Kwok Woon; Liao, Chun Hsing; Hsu, Chin-Wung; Chang, Feng Yi; Ko, Wen Chien; Chen, Ray-Jade; Wu, Jiunn Jong; Chen, Yen Hsu; Chen, Yao Shen; Liu, Jien Wei; Lu, Min Chi; Lam, Carlos; Liu, Cheng Yi; Hsueh, Po Ren.

於: Journal of Microbiology, Immunology and Infection, 卷 49, 編號 6, 01.12.2016, p. 969-976.

研究成果: 雜誌貢獻文章

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title = "Rates of susceptibility of carbapenems, ceftobiprole, and colistin against clinically important bacteria collected from intensive care units in 2007: Results from the Surveillance of Multicenter Antimicrobial Resistance in Taiwan (SMART)",
abstract = "Background: Data on susceptibility to ceftobiprole and colistin, and the complete evolutionary trends of minimum inhibitory concentrations (MICs) of important carbapenem agents among important pathogens collected in intensive care units (ICUs) in Taiwan are lacking. Methods: We surveyed the MIC distribution patterns of ceftobiprole and colistin and susceptibility profiles of some important pathogens collected from patients hospitalized in intensive care units (ICUs) of major teaching hospitals throughout Taiwan in 2007. We also investigated the rates of nonsusceptibility to powerful carbapenems (imipenem, meropenem) among four important species of Enterobacteriaceae (Escherichia coli, Klebsiella pneumoniae, Enterobacter cloacae, and Proteus mirabilis) collected during the same period. MIC breakpoints recommended by the Clinical and Laboratory Standards Institute in 2014 were applied. Results: Colistin showed excellent invitro activity (susceptibility rate, 96{\%}) against Acinetobacter baumannii isolates but moderate (73-77{\%} susceptibility rate) activity against isolates of Pseudomonas aeruginosa and E. cloacae. The ceftobiprole MIC90 value was 4μg/mL for methicillin-resistant Staphylococcus aureus and 16μg/mL for P. aeruginosa. The phenotype of methicillin resistance did not markedly increase the MIC value of ceftobiprole among S. aureus isolates. Interestingly, the proportion of isolates that displayed nonsusceptibility to imipenem was significantly higher among P. mirabilis isolates than among isolates of the other three Enterobacteriaceae species, regardless of the production of extended-spectrum β-lactamase. Conclusion: Continuous monitoring of susceptibility profiles of ICU pathogens to important antibiotics is warranted to provide appropriate antimicrobial regimens against infections in the ICU.",
keywords = "Carbapenem, Ceftobiprole, Colistin, Intensive care unit, Nonsusceptibility",
author = "ShioShin Jean and Wen-Sen Lee and Yu, {Kwok Woon} and Liao, {Chun Hsing} and Chin-Wung Hsu and Chang, {Feng Yi} and Ko, {Wen Chien} and Ray-Jade Chen and Wu, {Jiunn Jong} and Chen, {Yen Hsu} and Chen, {Yao Shen} and Liu, {Jien Wei} and Lu, {Min Chi} and Carlos Lam and Liu, {Cheng Yi} and Hsueh, {Po Ren}",
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T1 - Rates of susceptibility of carbapenems, ceftobiprole, and colistin against clinically important bacteria collected from intensive care units in 2007

T2 - Results from the Surveillance of Multicenter Antimicrobial Resistance in Taiwan (SMART)

AU - Jean, ShioShin

AU - Lee, Wen-Sen

AU - Yu, Kwok Woon

AU - Liao, Chun Hsing

AU - Hsu, Chin-Wung

AU - Chang, Feng Yi

AU - Ko, Wen Chien

AU - Chen, Ray-Jade

AU - Wu, Jiunn Jong

AU - Chen, Yen Hsu

AU - Chen, Yao Shen

AU - Liu, Jien Wei

AU - Lu, Min Chi

AU - Lam, Carlos

AU - Liu, Cheng Yi

AU - Hsueh, Po Ren

PY - 2016/12/1

Y1 - 2016/12/1

N2 - Background: Data on susceptibility to ceftobiprole and colistin, and the complete evolutionary trends of minimum inhibitory concentrations (MICs) of important carbapenem agents among important pathogens collected in intensive care units (ICUs) in Taiwan are lacking. Methods: We surveyed the MIC distribution patterns of ceftobiprole and colistin and susceptibility profiles of some important pathogens collected from patients hospitalized in intensive care units (ICUs) of major teaching hospitals throughout Taiwan in 2007. We also investigated the rates of nonsusceptibility to powerful carbapenems (imipenem, meropenem) among four important species of Enterobacteriaceae (Escherichia coli, Klebsiella pneumoniae, Enterobacter cloacae, and Proteus mirabilis) collected during the same period. MIC breakpoints recommended by the Clinical and Laboratory Standards Institute in 2014 were applied. Results: Colistin showed excellent invitro activity (susceptibility rate, 96%) against Acinetobacter baumannii isolates but moderate (73-77% susceptibility rate) activity against isolates of Pseudomonas aeruginosa and E. cloacae. The ceftobiprole MIC90 value was 4μg/mL for methicillin-resistant Staphylococcus aureus and 16μg/mL for P. aeruginosa. The phenotype of methicillin resistance did not markedly increase the MIC value of ceftobiprole among S. aureus isolates. Interestingly, the proportion of isolates that displayed nonsusceptibility to imipenem was significantly higher among P. mirabilis isolates than among isolates of the other three Enterobacteriaceae species, regardless of the production of extended-spectrum β-lactamase. Conclusion: Continuous monitoring of susceptibility profiles of ICU pathogens to important antibiotics is warranted to provide appropriate antimicrobial regimens against infections in the ICU.

AB - Background: Data on susceptibility to ceftobiprole and colistin, and the complete evolutionary trends of minimum inhibitory concentrations (MICs) of important carbapenem agents among important pathogens collected in intensive care units (ICUs) in Taiwan are lacking. Methods: We surveyed the MIC distribution patterns of ceftobiprole and colistin and susceptibility profiles of some important pathogens collected from patients hospitalized in intensive care units (ICUs) of major teaching hospitals throughout Taiwan in 2007. We also investigated the rates of nonsusceptibility to powerful carbapenems (imipenem, meropenem) among four important species of Enterobacteriaceae (Escherichia coli, Klebsiella pneumoniae, Enterobacter cloacae, and Proteus mirabilis) collected during the same period. MIC breakpoints recommended by the Clinical and Laboratory Standards Institute in 2014 were applied. Results: Colistin showed excellent invitro activity (susceptibility rate, 96%) against Acinetobacter baumannii isolates but moderate (73-77% susceptibility rate) activity against isolates of Pseudomonas aeruginosa and E. cloacae. The ceftobiprole MIC90 value was 4μg/mL for methicillin-resistant Staphylococcus aureus and 16μg/mL for P. aeruginosa. The phenotype of methicillin resistance did not markedly increase the MIC value of ceftobiprole among S. aureus isolates. Interestingly, the proportion of isolates that displayed nonsusceptibility to imipenem was significantly higher among P. mirabilis isolates than among isolates of the other three Enterobacteriaceae species, regardless of the production of extended-spectrum β-lactamase. Conclusion: Continuous monitoring of susceptibility profiles of ICU pathogens to important antibiotics is warranted to provide appropriate antimicrobial regimens against infections in the ICU.

KW - Carbapenem

KW - Ceftobiprole

KW - Colistin

KW - Intensive care unit

KW - Nonsusceptibility

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