Rapidly self-expandable polymeric stents with a shape-memory property

Mei Chin Chen, Hung Wen Tsai, Yen Chang, Wei Yun Lai, Fwu Long Mi, Chin Tang Liu, Hen Sheng Wong, Hsing Wen Sung

研究成果: 雜誌貢獻文章同行評審

127 引文 斯高帕斯(Scopus)


A novel biodegradable stent, made of chitosan films cross-linked with an epoxy compound, with a shape-memory property was developed. To reduce their crystallinity, glycerol and poly(ethylene oxide) were blended in the chitosan films. The mechanical properties of the prepared stent were studied using a commercially available metallic stent as a control. After blending, the ductility of the chitosan films was improved, and the compressive strength of the stent was significantly enhanced. The metallic stent could tolerate elastic deformations of 10% before becoming irreversibly deformed, while the polymeric stent was able to withstand deformations up to 30% and still regain its original configuration. The developed stent could rapidly expand (∼150 s) from its crimped (temporary) to fully expanded (permanent) states stimulated by hydration, which is advantageous considering avoiding its migration during in vivo deployment. In the preliminary animal study, the implanted stent was found to be intact, and no thrombus formation was seen in the stent-implanted vessel. This degradable stent can be an attractive alternative to metallic stents and may serve as a useful vehicle for local drug delivery.

頁(從 - 到)2774-2780
出版狀態已發佈 - 九月 2007

ASJC Scopus subject areas

  • 有機化學
  • 生物化學、遺傳與分子生物學 (全部)
  • 聚合物和塑料
  • 材料化學


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