Rapid correction of metabolic acidosis in chronic renal failure: Effect on parathyroid hormone activity

K. C. Lu, S. D. Shieh, B. L. Li, P. Chu, S. Y. Jan, Y. F. Lin

研究成果: 雜誌貢獻文章

21 引文 斯高帕斯(Scopus)

摘要

To investigate the effect of rapid correction of chronic metabolic acidosis on circulating intact parathyroid hormone (I-PTH) activity by free calcium clamp in chronic renal failure, 18 patients were enrolled in this study. Metabolic acidosis was corrected by continuous bicarbonate infusion while plasma ionized calcium was clamped at the preinfusion level throughout the entire procedure. The plasma pH, bicarbonate, total CO2, sodium, serum total calcium and 1,25(OH)2 vitamin D3 levels increased significantly while serum concentrations of I-PTH, alkaline phosphatase and albumin showed significant decreases after bicarbonate infusion. The plasma ionized calcium, potassium, serum magnesium and inorganic phosphorus levels showed no significant difference before and after bicarbonate infusion. These results demonstrate that rapid correction of metabolic acidosis attenuates circulating PTH activity in chronic renal failure and may underline the importance of maintaining normal acid-base homeostasis particularly in the presence of secondary hyperparathyroidism.

原文英語
頁(從 - 到)419-424
頁數6
期刊Nephron
67
發行號4
出版狀態已發佈 - 1994
對外發佈Yes

ASJC Scopus subject areas

  • Nephrology

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  • 引用此

    Lu, K. C., Shieh, S. D., Li, B. L., Chu, P., Jan, S. Y., & Lin, Y. F. (1994). Rapid correction of metabolic acidosis in chronic renal failure: Effect on parathyroid hormone activity. Nephron, 67(4), 419-424.