Radiosurgical target distance from the root entry zone in the treatment of trigeminal neuralgia

Justin Sharim, Wei Lun Lo, Won Kim, Srinivas Chivukula, Stephen Tenn, Tania Kaprealian, Nader Pouratian

研究成果: 雜誌貢獻文章同行評審

8 引文 斯高帕斯(Scopus)

摘要

Purpose Stereotactic radiosurgery (SRS) provides a noninvasive treatment modality for patients with medically refractory trigeminal neuralgia. The root entry zone (REZ) has been proposed to be an ideal stereotactic target because it is partially composed of centrally produced myelin, conferring a theoretical increased sensitivity to irradiation as well as increased susceptibility to neurovascular conflict, making it the site in which nociceptive signals likely arise. The aim of this study is to determine if there is a statistically and clinically significant difference in pain relief or facial hypesthesia following SRS based on distance of the stereotactic isocenter from REZ. Methods and materials Patients undergoing Novalis radiosurgery for the treatment of trigeminal neuralgia with at least 3 months’ follow-up were included in this study. Postoperative outcomes were stratified by Barrow Neurological Institute (BNI) score for pain relief and BNI facial numbness score for facial hypesthesia. Results Sixty-seven patients met inclusion criteria and were included in this study. BNI score of I-IIIa was attained in 82% of patients at 3 months and 65% at 1 year following SRS. Distance from isocenter to REZ varied from 0 to 8.6 mm, with a mean of 1.94 ± 1.62 mm. Logistic regression of target-REZ distance against pain relief outcome (patients with score I-IIIa and IIIb-V) was insignificant at 3 months (P =.988), 6 months (P =.925), 9 months (P =.845), and 12 months (P =.547) postoperatively. Furthermore, no significant correlation was found with logistic regression of target-REZ distance with pain relief outcome (patients with score I and score II-IV) (P =.544). Conclusions The current analysis suggests that distance from REZ does not correlate with degree of postoperative pain relief or facial hypesthesia; thus, targeting specific regions within the trigeminal nerve in relation to these anatomical characteristics may not afford any advantage from this perspective.
原文英語
頁(從 - 到)221-227
頁數7
期刊Practical Radiation Oncology
7
發行號4
DOIs
出版狀態已發佈 - 7月 2017

ASJC Scopus subject areas

  • 腫瘤科
  • 放射學、核子醫學和影像學

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