Radioresistance of cancer cells, integrin αvβ3 and thyroid hormone

John T. Leith, Shaker A. Mousa, Aleck Hercbergs, Hung Yun Lin, Paul J. Davis

研究成果: 雜誌貢獻回顧型文獻同行評審

7 引文 斯高帕斯(Scopus)

摘要

Radioresistance is a substantial barrier to success in cancer management. A number of molecular mechanisms support radioresistance. We have shown experimentally that the thyroid hormone analogue receptor on the extracellular domain of integrin αvβ3 may modulate the state of radiosensitivity of tumor cells. Specifically, tetraiodothyroacetic acid (tetrac), a derivative of L-thyroxine (T4), can reduce radioresistance in cancer cells. In this review, we list a number of intrinsic signal transduction molecules and other host factors that have been reported to support/induce radioresistance in cancer cells and that are also subject to control by T4 through actions primarily initiated at integrin αvβ3. Additional preclinical evidence is needed to support these radioresistance-relevant actions of thyroid hormone.
原文英語
頁(從 - 到)37069-37075
頁數7
期刊Oncotarget
9
發行號97
出版狀態已發佈 - 十二月 1 2018

ASJC Scopus subject areas

  • Oncology

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