Radioimmunotherapy of xenografted human bladder cancer using monoclonal antibody against blood group A-related antigen

M. Y. Yeh, D. S. Yu, S. Y. Chang, C. P. Ma, S. H. Han

研究成果: 雜誌貢獻文章同行評審

1 引文 斯高帕斯(Scopus)

摘要

An IgG3 murine monoclonal antibody 1G3.10 was generated against a human urinary bladder carcinoma cell line TSGH-8301. The tumor-associated antigen recognized by the monoclonal antibody is a blood group A-related substance. From fluorescence-activated cell sorter analysis, a direct cytolytic effect of tumor cells by the antibody at concentrations of more than 10 μg/ml was seen. The antibody could target iodine-131 to established subcutaneous human bladder carcinoma xenografts in BALB/c nude mice. Monoclonal antibody alone also showed some inhibitory effect on xenografted tumor growth. In this study, radiolabeled monoclonal antibody 1G3.10 presented more effective cytotoxicity than antibody alone from in vitro and in vivo experiments.

原文英語
頁(從 - 到)386-390
頁數5
期刊European Urology
14
發行號5
DOIs
出版狀態已發佈 - 一月 1 1988
對外發佈Yes

ASJC Scopus subject areas

  • Urology

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