Radiation-Sensitive Dendrimer-Based Drug Delivery System

Szu Yuan Wu, Hsiao Ying Chou, Chiou Hwa Yuh, Shewaye Lakew Mekuria, Yu Chih Kao, Hsieh Chih Tsai

研究成果: 雜誌貢獻文章

14 引文 (Scopus)

摘要

Combination of chemotherapy and radiotherapy is used to enhance local drug delivery while reducing off-target tissue effects. Anticancer drug doxorubicin (DOX) is loaded into l-cysteine modified G4.5 dendrimer (GC/DOX) and released at different pH values in the presence and absence of γ-radiation. Presence of γ-radiation significantly improves DOX release from the GC/DOX under acidic pH conditions, suggesting that GC dendrimer is a radiation-sensitive drug delivery system. GC/DOX is further evaluated by determining cytotoxicity in uterine cervical carcinoma HeLa cells. GC/DOX shows high affinity for cancer cells and effective drug release following an external stimulus (radiation exposure), whereas an in vivo zebrafish study confirms that l-cysteine acts as a radiosensitizer. GC/DOX treatment combined with radiotherapy synergistically and successfully inhibits cancer cell growth.

原文英語
期刊Advanced Science
5
發行號2
DOIs
出版狀態已發佈 - 二月 2018

指紋

Dendrimers
dendrimers
Drug Delivery Systems
Doxorubicin
delivery
drugs
Radiation
cancer
cysteine
Radiotherapy
radiation
radiation therapy
Chemotherapy
radiation dosage
Cell growth
chemotherapy
Cytotoxicity
Cysteine
Drug delivery
stimuli

ASJC Scopus subject areas

  • Medicine (miscellaneous)
  • Chemical Engineering(all)
  • Materials Science(all)
  • Biochemistry, Genetics and Molecular Biology (miscellaneous)
  • Engineering(all)
  • Physics and Astronomy(all)

引用此文

Wu, S. Y., Chou, H. Y., Yuh, C. H., Mekuria, S. L., Kao, Y. C., & Tsai, H. C. (2018). Radiation-Sensitive Dendrimer-Based Drug Delivery System. Advanced Science, 5(2). https://doi.org/10.1002/advs.201700339

Radiation-Sensitive Dendrimer-Based Drug Delivery System. / Wu, Szu Yuan; Chou, Hsiao Ying; Yuh, Chiou Hwa; Mekuria, Shewaye Lakew; Kao, Yu Chih; Tsai, Hsieh Chih.

於: Advanced Science, 卷 5, 編號 2, 02.2018.

研究成果: 雜誌貢獻文章

Wu, SY, Chou, HY, Yuh, CH, Mekuria, SL, Kao, YC & Tsai, HC 2018, 'Radiation-Sensitive Dendrimer-Based Drug Delivery System', Advanced Science, 卷 5, 編號 2. https://doi.org/10.1002/advs.201700339
Wu, Szu Yuan ; Chou, Hsiao Ying ; Yuh, Chiou Hwa ; Mekuria, Shewaye Lakew ; Kao, Yu Chih ; Tsai, Hsieh Chih. / Radiation-Sensitive Dendrimer-Based Drug Delivery System. 於: Advanced Science. 2018 ; 卷 5, 編號 2.
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