Radiation-Sensitive Dendrimer-Based Drug Delivery System

Szu Yuan Wu, Hsiao Ying Chou, Chiou Hwa Yuh, Shewaye Lakew Mekuria, Yu Chih Kao, Hsieh Chih Tsai

研究成果: 雜誌貢獻文章

21 引文 斯高帕斯(Scopus)

摘要

Combination of chemotherapy and radiotherapy is used to enhance local drug delivery while reducing off-target tissue effects. Anticancer drug doxorubicin (DOX) is loaded into l-cysteine modified G4.5 dendrimer (GC/DOX) and released at different pH values in the presence and absence of γ-radiation. Presence of γ-radiation significantly improves DOX release from the GC/DOX under acidic pH conditions, suggesting that GC dendrimer is a radiation-sensitive drug delivery system. GC/DOX is further evaluated by determining cytotoxicity in uterine cervical carcinoma HeLa cells. GC/DOX shows high affinity for cancer cells and effective drug release following an external stimulus (radiation exposure), whereas an in vivo zebrafish study confirms that l-cysteine acts as a radiosensitizer. GC/DOX treatment combined with radiotherapy synergistically and successfully inhibits cancer cell growth.

原文英語
文章編號1700339
期刊Advanced Science
5
發行號2
DOIs
出版狀態已發佈 - 二月 2018

ASJC Scopus subject areas

  • Medicine (miscellaneous)
  • Chemical Engineering(all)
  • Biochemistry, Genetics and Molecular Biology (miscellaneous)
  • Materials Science(all)
  • Engineering(all)
  • Physics and Astronomy(all)

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