Radiation-induced malignant fibrous histiocytoma in patients with nasopharyngeal carcinoma

Jenq Yuh Ko, Chi Long Chen, Louis Tak Lui, Mow Ming Hsu

研究成果: 雜誌貢獻文章

46 引文 (Scopus)

摘要

Objective: To evaluate the prevalence, 15-year cumulative incidence, time interval, and prognosis of radiation-induced malignant fibrous histiocytoma of the head and neck in long-term survivors of nasopharyngeal carcinoma. Design: Cohort. Setting: Tertiary care hospital. Patients: Eight long-term survivors of nasopharyngeal carcinoma with malignant fibrous histiocytoma in the maxillary sinus or nasal cavity. Main Outcome Measurement: Survival of postirradiation malignant fibrous histiocytoma in patients with nasopharyngeal carcinoma. Results: The prevalence of radiation-induced malignant fibrous histiocytoma in long-term survivors of nasopharyngeal carcinoma was 0.38%. The 15-year cumulative incidence was 2.2%. Most tumors occurred in the maxillary sinus and were characterized by spindle-shaped tumor cells with plump nuclei arranged in a whorl or storiform pattern in a fibrous stroma. The mean interval between malignant fibrous histiocytoma and nasopharyngeal carcinoma was 121 months. Local recurrence developed in all cases within 9 months after surgery. Six patients died of disease without distant metastasis within 30 months. Two patients were alive with disease for 10 and 32 months, respectively. Conclusions: Radiation-induced malignant fibrous histiocytoma in the head and neck region in long-term survivors of nasopharyngeal carcinoma is rare. It takes a long time to occur after irradiation and is locally invasive with poor prognosis.

原文英語
頁(從 - 到)533-538
頁數6
期刊Archives of Otolaryngology - Head and Neck Surgery
122
發行號5
出版狀態已發佈 - 五月 1996
對外發佈Yes

指紋

Malignant Fibrous Histiocytoma
Radiation
Survivors
Maxillary Sinus
Neck
Head
Nasal Cavity
Incidence
Tertiary Healthcare
Tertiary Care Centers
Nasopharyngeal carcinoma
Neoplasms
Neoplasm Metastasis
Recurrence
Survival

ASJC Scopus subject areas

  • Otorhinolaryngology

引用此文

Radiation-induced malignant fibrous histiocytoma in patients with nasopharyngeal carcinoma. / Ko, Jenq Yuh; Chen, Chi Long; Lui, Louis Tak; Hsu, Mow Ming.

於: Archives of Otolaryngology - Head and Neck Surgery, 卷 122, 編號 5, 05.1996, p. 533-538.

研究成果: 雜誌貢獻文章

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abstract = "Objective: To evaluate the prevalence, 15-year cumulative incidence, time interval, and prognosis of radiation-induced malignant fibrous histiocytoma of the head and neck in long-term survivors of nasopharyngeal carcinoma. Design: Cohort. Setting: Tertiary care hospital. Patients: Eight long-term survivors of nasopharyngeal carcinoma with malignant fibrous histiocytoma in the maxillary sinus or nasal cavity. Main Outcome Measurement: Survival of postirradiation malignant fibrous histiocytoma in patients with nasopharyngeal carcinoma. Results: The prevalence of radiation-induced malignant fibrous histiocytoma in long-term survivors of nasopharyngeal carcinoma was 0.38{\%}. The 15-year cumulative incidence was 2.2{\%}. Most tumors occurred in the maxillary sinus and were characterized by spindle-shaped tumor cells with plump nuclei arranged in a whorl or storiform pattern in a fibrous stroma. The mean interval between malignant fibrous histiocytoma and nasopharyngeal carcinoma was 121 months. Local recurrence developed in all cases within 9 months after surgery. Six patients died of disease without distant metastasis within 30 months. Two patients were alive with disease for 10 and 32 months, respectively. Conclusions: Radiation-induced malignant fibrous histiocytoma in the head and neck region in long-term survivors of nasopharyngeal carcinoma is rare. It takes a long time to occur after irradiation and is locally invasive with poor prognosis.",
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AU - Lui, Louis Tak

AU - Hsu, Mow Ming

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N2 - Objective: To evaluate the prevalence, 15-year cumulative incidence, time interval, and prognosis of radiation-induced malignant fibrous histiocytoma of the head and neck in long-term survivors of nasopharyngeal carcinoma. Design: Cohort. Setting: Tertiary care hospital. Patients: Eight long-term survivors of nasopharyngeal carcinoma with malignant fibrous histiocytoma in the maxillary sinus or nasal cavity. Main Outcome Measurement: Survival of postirradiation malignant fibrous histiocytoma in patients with nasopharyngeal carcinoma. Results: The prevalence of radiation-induced malignant fibrous histiocytoma in long-term survivors of nasopharyngeal carcinoma was 0.38%. The 15-year cumulative incidence was 2.2%. Most tumors occurred in the maxillary sinus and were characterized by spindle-shaped tumor cells with plump nuclei arranged in a whorl or storiform pattern in a fibrous stroma. The mean interval between malignant fibrous histiocytoma and nasopharyngeal carcinoma was 121 months. Local recurrence developed in all cases within 9 months after surgery. Six patients died of disease without distant metastasis within 30 months. Two patients were alive with disease for 10 and 32 months, respectively. Conclusions: Radiation-induced malignant fibrous histiocytoma in the head and neck region in long-term survivors of nasopharyngeal carcinoma is rare. It takes a long time to occur after irradiation and is locally invasive with poor prognosis.

AB - Objective: To evaluate the prevalence, 15-year cumulative incidence, time interval, and prognosis of radiation-induced malignant fibrous histiocytoma of the head and neck in long-term survivors of nasopharyngeal carcinoma. Design: Cohort. Setting: Tertiary care hospital. Patients: Eight long-term survivors of nasopharyngeal carcinoma with malignant fibrous histiocytoma in the maxillary sinus or nasal cavity. Main Outcome Measurement: Survival of postirradiation malignant fibrous histiocytoma in patients with nasopharyngeal carcinoma. Results: The prevalence of radiation-induced malignant fibrous histiocytoma in long-term survivors of nasopharyngeal carcinoma was 0.38%. The 15-year cumulative incidence was 2.2%. Most tumors occurred in the maxillary sinus and were characterized by spindle-shaped tumor cells with plump nuclei arranged in a whorl or storiform pattern in a fibrous stroma. The mean interval between malignant fibrous histiocytoma and nasopharyngeal carcinoma was 121 months. Local recurrence developed in all cases within 9 months after surgery. Six patients died of disease without distant metastasis within 30 months. Two patients were alive with disease for 10 and 32 months, respectively. Conclusions: Radiation-induced malignant fibrous histiocytoma in the head and neck region in long-term survivors of nasopharyngeal carcinoma is rare. It takes a long time to occur after irradiation and is locally invasive with poor prognosis.

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