Quercetin, a main flavonoid in onion, inhibits the PGF-induced uterine contraction in vitro and in vivo

Chi Hao Wu, Tzong Ming Shieh, Kai Lee Wang, Tsui Chin Huang, Shih Min Hsia

研究成果: 雜誌貢獻文章

8 引文 斯高帕斯(Scopus)

摘要

Dysmenorrhoea is considered to be caused by excessive levels of prostaglandins, which stimulate abnormal uterine contractions. This study aimed to investigate the modulatory effects of quercetin that is a main flavonoid in onion on uterine contractility and its possible underlying mechanisms. In vitro and in vivo contractile activities of the uteri were determined using uterine horns isolated from adult rats. The results indicated that (1) for contractions induced by PGF2α-, oxytocin-, and carbachol, quercetin showed the most potent suppressing effect among the tested flavonoids; (2) Ca2+-dependent uterine contractions were inhibited by quercetin; (3) quercetin reduced the PGF2α-elicited Ca2+ responses in human uterine smooth muscle cells; (4) quercetin inhibited uterine contractions stimulated by Ca2+ channel activator and depolarisation in response to high K+; (5) quercetin was able to block Ca2+ influx through voltage-operated Ca2+ channels in plasma membrane; and (6) quercetin effectively reduced PGF2α-induced contractions through the administration of increasing doses of 10, 25, and 50 mg/kg in rats. The present findings suggest that onion's major active compound, quercetin, may be a potential adjuvant for treating uterine disorders.
原文英語
文章編號1300
頁(從 - 到)495-504
頁數10
期刊Journal of Functional Foods
19
DOIs
出版狀態已發佈 - 十二月 1 2015

ASJC Scopus subject areas

  • Food Science
  • Medicine (miscellaneous)
  • Nutrition and Dietetics

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