Quantitative MR relaxometry study of muscle composition and function in Duchenne muscular dystrophy.

Y. Huang, S. Majumdar, H. K. Genant, W. P. Chan, K. R. Sharma, P. Yu, M. Mynhier, R. G. Miller

研究成果: 雜誌貢獻文章同行評審

84 引文 斯高帕斯(Scopus)

摘要

Magnetic resonance imaging and maps of T1 and T2 values were used to study muscle composition in Duchenne muscular dystrophy (DMD). The mean T2 of anterior tibial muscle was 27 msec in healthy control subjects and 43 msec with increased fatty infiltration in DMD patients. In stronger DMD patients, the distribution of muscle T2 values was narrow, centered at 27 msec as in the controls, with a nonoverlapping fat peak centered at 49 msec. In weaker DMD patients, the width of the muscle T2 peak increased and the peak shifted toward the fat peak. Mean muscle T1 decreased from 1.7 to 0.6 second with increasing fatty infiltration. These results show that quantitative T1 and T2 maps may be used to assess muscle status and monitor DMD progression.

原文英語
頁(從 - 到)59-64
頁數6
期刊Journal of Magnetic Resonance Imaging
4
發行號1
出版狀態已發佈 - 1月 1994
對外發佈

ASJC Scopus subject areas

  • 放射學、核子醫學和影像學
  • 放射與超音波技術

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