Quantitative Examination of the Active Targeting Effect: The Key Factor for Maximal Tumor Accumulation and Retention of Short-Circulated Biopolymeric Nanocarriers

Jianquan Wang, Gee Young Lee, Qian Lu, Xianghong Peng, Jiangxiao Wu, Siyuan Wu, Brad A. Kairdolf, Shuming Nie, Yiqing Wang, Lucas A. Lane

研究成果: 雜誌貢獻文章同行評審

6 引文 斯高帕斯(Scopus)

摘要

Targeted and nontargeted biopolymeric nanoparticles with identical hydrodynamic sizes and surface charges were quantitatively examined in terms of the pharmacokinetic and biodistribution differences in detail. In adding cancer cell targeting folate molecules to the surface of the heparin nanocarriers, the amount of drug delivered to the tumor is doubled, and tumor growth inhibition is significantly enhanced. The folate-targeted heparin particles offered similar therapeutic potentials compared to their synthetic long-circulating analogues, thus presenting a viable alternative for drug-delivery vehicle construction using biological polymers, which are easier for the body to eliminate.
原文英語
頁(從 - 到)1351-1355
頁數5
期刊Bioconjugate Chemistry
28
發行號5
DOIs
出版狀態已發佈 - 5月 17 2017
對外發佈

ASJC Scopus subject areas

  • 生物技術
  • 生物工程
  • 生物醫學工程
  • 藥理
  • 藥學科學
  • 有機化學

指紋

深入研究「Quantitative Examination of the Active Targeting Effect: The Key Factor for Maximal Tumor Accumulation and Retention of Short-Circulated Biopolymeric Nanocarriers」主題。共同形成了獨特的指紋。

引用此