Quantitative analysis of CDKN2, p53 and retinoblastoma mRNA in human gastric carcinoma

Yi Jen Chen, Li Sun Shih, Yi Ming A. Chen

研究成果: 雜誌貢獻文章

10 引文 斯高帕斯(Scopus)

摘要

The mRNA level of CDKN2 (p16), retinoblastoma (Rb) and p53 in cancerous and non-cancerous tissue samples were compared using a semi-quantitative reverse-transcription-polymerase chain reaction method. The mean CDKN2 mRNA level of 10 gastric cancer specimens was significantly higher than that of their non-cancerous tissue samples (p=0.039). In contrast, the mRNA levels of Rb and p53 in gastric cancer tissues were both significantly lower than those in their noncancerous tissue samples. Furthermore, both mRNA ratios of Rb/CDKN2 and p53/CDKN2 were significantly decreased in gastric cancer tissues. Therefore, suppression of both Rb and p53 and overexpression of CDKN2 may be associated with the tumorigenesis of gastric cancer.
原文英語
頁(從 - 到)249-254
頁數6
期刊International Journal of Oncology
13
發行號2
出版狀態已發佈 - 八月 1 1998
對外發佈Yes

ASJC Scopus subject areas

  • Oncology
  • Cancer Research

指紋 深入研究「Quantitative analysis of CDKN2, p53 and retinoblastoma mRNA in human gastric carcinoma」主題。共同形成了獨特的指紋。

  • 引用此