Quantification Analysis of Sleep Based on Smartwatch Sensors for Parkinson’s Disease

Yi Feng Ko, Pei Hsin Kuo, Ching Fu Wang, Yu Jen Chen, Pei Chi Chuang, Shih Zhang Li, Bo Wei Chen, Fu Chi Yang, Yu Chun Lo, Yi Yang, Shuan Chu Vina Ro, Fu Shan Jaw, Sheng Huang Lin, You Yin Chen

研究成果: 雜誌貢獻文章同行評審

摘要

Rapid eye movement (REM) sleep behavior disorder (RBD) is associated with Parkinson’s disease (PD). In this study, a smartwatch-based sensor is utilized as a convenient tool to detect the abnormal RBD phenomenon in PD patients. Instead, a questionnaire with sleep quality assessment and sleep physiological indices, such as sleep stage, activity level, and heart rate, were measured in the smartwatch sensors. Therefore, this device can record comprehensive sleep physiological data, offering several advantages such as ubiquity, long-term monitoring, and wearable convenience. In addition, it can provide the clinical doctor with sufficient information on the patient’s sleeping pat-terns with individualized treatment. In this study, a three-stage sleep staging method (i.e., comprising sleep/awake detection, sleep-stage detection, and REM-stage detection) based on an accelerometer and heart-rate data is implemented using machine learning (ML) techniques. The ML-based algorithms used here for sleep/awake detection, sleep-stage detection, and REM-stage detection were a Cole–Kripke algorithm, a stepwise clustering algorithm, and a k-means clustering algorithm with predefined criteria, respectively. The sleep staging method was validated in a clinical trial. The results showed a statistically significant difference in the percentage of abnormal REM between the control group (1.6 ± 1.3; n = 18) and the PD group (3.8 ± 5.0; n = 20) (p = 0.04). The percentage of deep sleep stage in our results presented a significant difference between the control group (38.1 ± 24.3; n = 18) and PD group (22.0 ± 15.0, n = 20) (p = 0.011) as well. Further, our results suggested that the smartwatch-based sensor was able to detect the difference of an abnormal REM percentage in the control group (1.6 ± 1.3; n = 18), PD patient with clonazepam (2.0 ± 1.7; n = 10), and without clonazepam (5.7 ± 7.1; n = 10) (p = 0.007). Our results confirmed the effectiveness of our sensor in investigating the sleep stage in PD patients. The sensor also successfully determined the effect of clonazepam on reducing abnormal REM in PD patients. In conclusion, our smartwatch sensor is a convenient and effective tool for sleep quantification analysis in PD patients.

原文英語
文章編號74
期刊Biosensors
12
發行號2
DOIs
出版狀態已發佈 - 2月 2022

ASJC Scopus subject areas

  • 臨床生物化學

指紋

深入研究「Quantification Analysis of Sleep Based on Smartwatch Sensors for Parkinson’s Disease」主題。共同形成了獨特的指紋。

引用此