Purine analogues as kinase inhibitors: A review

Sahil Sharma, Samir Mehndiratta, Sunil Kumar, Jagjeet Singh, Preet M.S. Bedi, Kunal Nepali

研究成果: 雜誌貢獻回顧型文獻同行評審

20 引文 斯高帕斯(Scopus)

摘要

Protein kinases constitute one of the largest and most functionally diverse gene families that regulate key cell functions. In past several years, kinase inhibition has emerged as potential anti-cancer drug target. Purine is a priveleged heterocyclicnucleus which exists in the chemical architecture of various bioactive compounds. Numerous reports on the use of purine analogues in the treatment of acute leukemias (thiopurines, pentostatin), as antiviral (acyclovir, penciclovir, ganciclovir), as immunosuppressive (azathioprine), as antitumor (vidarabine), as bronchodilator (theophylline) have been revealed. In the past decade, purine analogues have emerged as significantly potent kinase inhibitors. A fair amount of research has been done and several patents have also been published highlighting the kinase inhibitory action of purines. Caffeine, 2- aminopurine, purvalanol-A, seleciclib, FSBA, adenosine thiol analogue possessing purine as the basic moiety fall under this category. In view of the use of purines for the inhibition of kinases, there is need for compilation of data specifying the prominence of purines in the treatment of cancer through this mechanism. The structure of the potent compounds, their IC50 values, models used and the enzymes/ receptors/ targets involved have been presented in this review. The present compilation covers the patents published entailing the purines as kinase inhibitors and the purine drugs employed in chemotherapy.
原文英語
頁(從 - 到)308-341
頁數34
期刊Recent Patents on Anti-Cancer Drug Discovery
10
發行號3
DOIs
出版狀態已發佈 - 十月 1 2015
對外發佈

ASJC Scopus subject areas

  • 腫瘤科
  • 藥物發現
  • 癌症研究
  • 藥學(醫學)

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