Pulsed high-intensity focused ultrasound enhances the relative permeability of the bloodtumor barrier in a glioma-bearing rat model

Feng Yi Yang, Guan Liang Lin, Shih Cheng Horng, Tien Kuei Chang, Shih Yen Wu, Tai-Tong Wong, Hsin Ell Wang

研究成果: 雜誌貢獻文章

36 引文 (Scopus)

摘要

The use of pulsed high-intensity focused ultrasound (HIFU) with an ultrasound contrast agent (UCA) has been shown to disrupt the blood-brain barrier (BBB) noninvasively and reversibly in the targeted regions. This study evaluated the relative permeability of the blood-tumor barrier (BTB) after sonication by pulsed HIFU. Entry into the brain of chemotherapeutic agents is impeded by the BBB even though the permeability of this barrier may be partially reduced in the presence of a brain tumor. F98 glioma-bearing rats were injected intravenously with Evans blue (EB) with or without BTB disruption induced by pulsed HIFU. Sonication was applied at an ultrasound frequency of 1 MHz with a 5% duty cycle, and a repetition frequency of 1 Hz. The accumulation of EB in brain tumor and the tumor-to-contralateral brain ratio of EB were highest after pulsed HIFU exposure. Sonication followed by EB injection showed a tumor-to-contralateral brain ratio in the target tumors which was about 2 times that of the control tumors. This research demonstrates that pulsed HIFU enhances the relative permeability of the BTB in glioma- bearing rats. The results of this pilot study support the idea that further evaluation of other treatment strategies, such as HIFU exposure in addition to combined chemotherapy or repeated pulsed HIFU exposure to increase delivery of drugs into brain tumors, might be useful.

原文英語
文章編號5776751
頁(從 - 到)964-970
頁數7
期刊IEEE Transactions on Ultrasonics, Ferroelectrics, and Frequency Control
58
發行號5
DOIs
出版狀態已發佈 - 五月 1 2011
對外發佈Yes

指紋

Bearings (structural)
rats
Rats
Tumors
permeability
tumors
Ultrasonics
brain
Brain
Sonication
blood-brain barrier
blood
Blood
drugs
Chemotherapy
chemotherapy
entry
repetition
delivery

ASJC Scopus subject areas

  • Electrical and Electronic Engineering
  • Acoustics and Ultrasonics
  • Instrumentation

引用此文

Pulsed high-intensity focused ultrasound enhances the relative permeability of the bloodtumor barrier in a glioma-bearing rat model. / Yang, Feng Yi; Lin, Guan Liang; Horng, Shih Cheng; Chang, Tien Kuei; Wu, Shih Yen; Wong, Tai-Tong; Wang, Hsin Ell.

於: IEEE Transactions on Ultrasonics, Ferroelectrics, and Frequency Control, 卷 58, 編號 5, 5776751, 01.05.2011, p. 964-970.

研究成果: 雜誌貢獻文章

Yang, Feng Yi ; Lin, Guan Liang ; Horng, Shih Cheng ; Chang, Tien Kuei ; Wu, Shih Yen ; Wong, Tai-Tong ; Wang, Hsin Ell. / Pulsed high-intensity focused ultrasound enhances the relative permeability of the bloodtumor barrier in a glioma-bearing rat model. 於: IEEE Transactions on Ultrasonics, Ferroelectrics, and Frequency Control. 2011 ; 卷 58, 編號 5. 頁 964-970.
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