Pulsatile ocular blood flow of choroidal neovascularization in asymmetric age-related macular degeneration after transpupillary thermotherapy

S. J. Chen, C. Y. Cheng, A. F. Lee, F. L. Lee, Wen-Ming Hsu, J. H. Liu

研究成果: 雜誌貢獻文章同行評審

7 引文 斯高帕斯(Scopus)

摘要

Purpose. A previous study has shown that the pulsatile ocular blood flow (POBF) in eyes with asymmetric age-related macular degeneration (AMD) differs. Whereas eyes with drusen have higher POBF than contralateral eyes with disciform scarring, the POBF of eyes with drusen is lower relative to contralateral eyes with choroidal neovascularization (CNV). This study was designed to assess whether the POBF of eyes with CNV changes after transpupillary thermotherapy (TTT), using the contralateral eyes with drusen or scarring without TTT as controls. Methods. In total, 26 patients with CNV in one eye and drusen or scarring in the other were enrolled in this prospective case series. Eyes with CNV were treated with TTT. POBF was measured monthly in both eyes of each subject. Results. Before TTT, the POBF of eyes with CNV was 1179 ± 317 μl/min. After TTT, the POBF of CNV eyes had decreased at 1 month (1015 ± 273 μl/min, P = 0.002) and 2 months (945 ± 398 μ l/min, P = 0.011) of follow-up, but had rebounded at 3 months (P = 0.441) and 6 months (P = 0.084). Conclusions. These findings suggest that TTT decreases the pulsatile choroidal blood flow in eyes with CNV in patients with asymmetric AMD and the effects persist for 2 months. POBF may be used as a modality to monitor the therapeutic effects of CNV in asymmetric exudative AMD.

原文英語
頁(從 - 到)595-599
頁數5
期刊Eye
18
發行號6
DOIs
出版狀態已發佈 - 一月 1 2004
對外發佈Yes

ASJC Scopus subject areas

  • Ophthalmology
  • Arts and Humanities(all)

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