Pulsatile ocular blood flow change after treatment with systemic steroid in patients with Graves' ophthalmopathy

C. C. Tsai, H. C. Kau, H. H. Tsai, S. C. Kao, Wen-Ming Hsu

研究成果: 雜誌貢獻文章

7 引文 斯高帕斯(Scopus)

摘要

Purpose: Our previous study has demonstrated an impairment of pulsatile ocular blood flow (POBF) in patients with Graves'ophthalmopathy (GO). Here we further evaluate the haemodynamic change in GO patients after systemic steroid. Methods: In a prospective, interventional, consecutive clinical case series, all patients with active and moderately severe GO who underwent systemic steroid treatment were evaluated. The change of POBF and the clinical activity and severity of the disease were assessed. Results: In total, 11 patients underwent intravenous methylprednisolone pulse therapy followed by 2-month oral prednisolone therapy. POBF improved from a mean value of 476.5 to 614.7μl/min (P<0.001) after treatment. Likewise, the mean clinical activity score reduced from 4.8 to 1.6. However, systemic steroid had less effect on the severity of GO. It also revealed that there is a greater improvement of POBF in those with more clinical activity score (>4) at the onset. Conclusions: Following treatment with systemic steroid we have demonstrated a significant improvement in POBF in patients with GO.

原文英語
頁(從 - 到)1025-1029
頁數5
期刊Eye
20
發行號9
DOIs
出版狀態已發佈 - 一月 1 2006
對外發佈Yes

ASJC Scopus subject areas

  • Ophthalmology
  • Arts and Humanities(all)

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