Pulmonary NAD+-linked 15-hydroxyprostaglandin dehydrogenase activity is decreased by cigarette smoking

Wen Chang Chang, Shoshi Fukuda, Hsin Hsiung Tai

研究成果: 雜誌貢獻文章同行評審

7 引文 斯高帕斯(Scopus)

摘要

Male rats were exposed to freshly generated cigarette smoke once daily for 4 to 13 weeks. Inhalation of smoke was verified by elevated level of carboxyhemoglobin. NAD+-dependent 15-hydroxyprostaglandin dehydrogenase activity, the key enzyme responsible for biological inactivation of prostaglandins, was found to decrease in lung but not in kidney or stomach following cigarette smoke exposure. The consequence of impaired pulmonary metobolism of prostaglandins and thromboxane may result in alteration of vascular homeostasis and subsequently lead to cardiovascular disorders commonly found in smokers.

原文英語
頁(從 - 到)1261-1268
頁數8
期刊Life Sciences
34
發行號13
DOIs
出版狀態已發佈 - 三月 26 1984
對外發佈Yes

ASJC Scopus subject areas

  • Pharmacology

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