Pu-erh tea attenuates smoking-induced foam cell formation through inhibition of the α9-nicotinic-acetylcholine receptor expression in monocytes: An ex vivo study

Li Ching Chen, Ming Yao Chen, Shih Hsin Tu, Min Hsiung Pan, Chih Yu Lo, Chi Tang Ho, Chih Hsiung Wu, Yuan Soon Ho

研究成果: 雜誌貢獻文章同行評審

1 引文 斯高帕斯(Scopus)

摘要

To assess whether drinking tea can effectively prevent smoking-induced atherosclerosis, a clinical trial ex vivo study was performed. The volunteers were randomly allocated to two groups (n = 55 per group) that received either Pu-erh tea powder or a cellulose placebo (0.5 g/capsule, T.I.D.) for two months. The circulating monocytes were isolated from the tested individuals after 0, 1, and 2 months of tea-capsule administration. We found that monocytes displaying high α9-nicotinic-acetylcholine-receptor (α9-nAchR) expression that were isolated from heavy smokers before consuming tea capsules tended to form foam cells in response to nicotine (1 μ L for 24 h, *P <0.001). In contrast, long-term tea consumption significantly downregulated the monocytic α9-nAchR expression (0 months vs. 1 and 2 months; #P = 0.013 and ##P = 0.004, respectively) which causes circulating monocytes to resist nicotine-induced foam cell formation even in heavy-smokers (*P <0.001). This study suggests that tea-drinking effectively attenuates the initial step (foam-cell formation) of smoking-induced atherosclerosis in circulating monocytes.
原文英語
頁(從 - 到)132-144
頁數13
期刊Journal of Functional Foods
22
DOIs
出版狀態已發佈 - 四月 1 2016

ASJC Scopus subject areas

  • Food Science
  • Medicine (miscellaneous)
  • Nutrition and Dietetics

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