Psychophysiological effects of lactobacillus plantarum ps128 in patients with major depressive disorder: A preliminary 8-week open trial

Hui Mei Chen, Po Hsiu Kuo, Chia Yueh Hsu, Yi Hung Chiu, Yen Wenn Liu, Mong Liang Lu, Chun Hsin Chen

研究成果: 雜誌貢獻文章同行評審

2 引文 斯高帕斯(Scopus)

摘要

Recent studies have suggested that gut–brain axis may be one of the mechanisms of major depression disorder (MDD). The current study aimed to investigate the effects of Lactobacillus planta-rum PS128 (PS128) on psychophysiology in patients with MDD. We recruited 11 patients with MDD and gave them PS128 for 8 weeks. We compared depression symptoms, serum markers of inflammation and gut permeability, and gut microbiota before and after 8-week intervention and also explored the correlations among symptoms, biomarkers, and gut microbiota. After 8-week PS128 intervention, scores of Hamilton Depression Rating Scale-17 and Depression and Somatic symptoms Scale significantly decreased. Serum levels of high sensitivity c-reactive protein, interluekin-6, and tumor necrosis factor-α, zonulin and intestinal fatty acid binding protein, and the composition of gut microbiota did not significantly change after 8-week PS128 intervention. However, we found changes of some genera were correlated with changes of symptoms and biomarkers. In con-clusion, this is an open trial with small sample size and has several limitations. The results need to be verified by randomized, double-blind, placebo-controlled trial with larger sample size.
原文英語
文章編號3731
期刊Nutrients
13
發行號11
DOIs
出版狀態已發佈 - 11月 2021

ASJC Scopus subject areas

  • 食品科學
  • 營養與營養學

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