Psoriasis is associated with an increased risk of parkinsonism: A population-based 5-year follow-up study

研究成果: 雜誌貢獻文章

15 引文 (Scopus)

摘要

Background: Few studies have examined the association between autoimmune diseases and parkinsonism. Objective: We sought to investigate the risk for parkinsonism during a 5-year follow-up period after a diagnosis of psoriasis using a population-based data set in Taiwan. Methods: We identified 4885 patients with psoriasis for the study cohort and randomly selected 24,425 patients as a control cohort. Each subject was individually followed up for a 5-year period to identify those who subsequently developed parkinsonism. Results: Stratified Cox proportional hazards regression showed that the adjusted hazard ratio for parkinsonism during the 5-year follow-up period for patients with psoriasis was 1.74 (95% confidence interval 1.35-2.20) that of control patients. Furthermore, the adjusted hazard ratios for parkinsonism within the 5-year follow-up period after the index date for subjects with psoriasis were similar between both sexes (1.78 and 1.66 for men and women, respectively). Limitation: Our data set did not provide detailed information on the severity of psoriasis, or individual factors such as cigarette smoking, alcohol consumption, body mass index, and dietary patterns. Conclusion: Patients with psoriasis were found to be at a significant risk of parkinsonism during a 5-year follow-up.
原文英語
頁(從 - 到)992-999
頁數8
期刊Journal of the American Academy of Dermatology
68
發行號6
DOIs
出版狀態已發佈 - 六月 2013

指紋

Parkinsonian Disorders
Psoriasis
Population
Taiwan
Alcohol Drinking
Autoimmune Diseases
Body Mass Index
Cohort Studies
Smoking
Confidence Intervals

ASJC Scopus subject areas

  • Dermatology

引用此文

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abstract = "Background: Few studies have examined the association between autoimmune diseases and parkinsonism. Objective: We sought to investigate the risk for parkinsonism during a 5-year follow-up period after a diagnosis of psoriasis using a population-based data set in Taiwan. Methods: We identified 4885 patients with psoriasis for the study cohort and randomly selected 24,425 patients as a control cohort. Each subject was individually followed up for a 5-year period to identify those who subsequently developed parkinsonism. Results: Stratified Cox proportional hazards regression showed that the adjusted hazard ratio for parkinsonism during the 5-year follow-up period for patients with psoriasis was 1.74 (95{\%} confidence interval 1.35-2.20) that of control patients. Furthermore, the adjusted hazard ratios for parkinsonism within the 5-year follow-up period after the index date for subjects with psoriasis were similar between both sexes (1.78 and 1.66 for men and women, respectively). Limitation: Our data set did not provide detailed information on the severity of psoriasis, or individual factors such as cigarette smoking, alcohol consumption, body mass index, and dietary patterns. Conclusion: Patients with psoriasis were found to be at a significant risk of parkinsonism during a 5-year follow-up.",
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