@article{7588f87ad99943ebba18790f5be2aa8c,
title = "Protopine, a novel microtubule-stabilizing agent, causes mitotic arrest and apoptotic cell death in human hormone-refractory prostate cancer cell lines",
abstract = "In this study, we investigated the anticancer effect of protopine on human hormone-refractory prostate cancer (HRPC) cells. Protopine exhibited an anti-proliferative effect by induction of tubulin polymerization and mitotic arrest, which ultimately led to apoptotic cell death. The data suggest that protopine increased the activity of cyclin-dependent kinase 1 (Cdk1)/cyclin B1 complex and that contributed to cell apoptosis by modulating mitochondria-mediated signaling pathways, such as Bcl-2 phosphorylation and Mcl-1 down-regulation. In conclusion, the data suggest that protopine is a novel microtubule stabilizer with anticancer activity in HRPC cells through apoptotic pathway by modulating Cdk1 activity and Bcl-2 family of proteins.",
keywords = "Apoptosis, Cdk1, Microtubules, Mitotic arrest, Protopine",
author = "Chun-Han Chen and Liao, {Cho Hwa} and Chang, {Ya Ling} and Guh, {Jih Hwa} and Pan, {Shiow Lin} and Teng, {Che Ming}",
note = "Funding Information: The authors would like to thank Dr. An-Chi Tsai and Miss Chin-Yu Lai for the technical assistance of tube formation assay. This work was supported by research grants of the National Science Council of the Republic of China (NSC 99-2320-B400-008-MY3, NSC 99-2628-B002-024-MY3). Copyright: Copyright 2012 Elsevier B.V., All rights reserved.",
year = "2012",
month = feb,
day = "1",
doi = "10.1016/j.canlet.2011.09.042",
language = "English",
volume = "315",
pages = "1--11",
journal = "Cancer Letters",
issn = "0304-3835",
publisher = "Elsevier Ireland Ltd",
number = "1",
}
