Proton pump inhibitor-related headaches: A nationwide population-based case-crossover study in Taiwan

Jen Feng Liang, Yung Tai Chen, Jong Ling Fuh, Szu Yuan Li, Tzeng Ji Chen, Chao Hsiun Tang, Shuu Jiun Wang

研究成果: 雜誌貢獻文章同行評審

7 引文 斯高帕斯(Scopus)

摘要

Background: Headaches resulting from proton pump inhibitor (PPI) use could cause discontinuation of PPI in as many as 40% of patients who experience such headaches. Previous studies focusing on acute headache risk from PPI use are rare and limited to clinical trials of a single PPI. Objectives: To investigate the association between PPI use and headache with a nationwide population-based case-crossover study. Methods: Records containing the first diagnosis of any headache, including migraine and tension-type headaches, were retrieved from Taiwan National Health Insurance Database (19982010).We compared the rates of PPI use for cases and controls during time windows of 7, 14, and 28 days. The adjusted self-matched odds ratios (ORs) and 95% confidence intervals (CIs) from a conditional logistic regression model were used to determine the association between PPI use and headache. Results: Overall, 314,210 patients with an initial diagnosis of any headache during the study period were enrolled. The adjusted ORs for headache risk after PPI exposure were calculated for three time periods (within 7 days1.41, p0.002, 95% CI 1.141.74; within 14 days1.36, p

原文英語
頁(從 - 到)203-210
頁數8
期刊Cephalalgia
35
發行號3
DOIs
出版狀態已發佈 - 三月 26 2015

ASJC Scopus subject areas

  • 神經病學(臨床)

指紋

深入研究「Proton pump inhibitor-related headaches: A nationwide population-based case-crossover study in Taiwan」主題。共同形成了獨特的指紋。

引用此