Proton magnetic resonance spectroscopy-guided biopsy for cerebral glial tumors

研究成果: 雜誌貢獻文章同行評審

9 引文 斯高帕斯(Scopus)

摘要

Background and Purpose: Although application of proton magnetic resonance (MR) spectroscopy in the diagnosis of brain tumors has been reported, the role of this technique as guidance for targeting biopsy of brain tumors is not well established. The usefulness and limitations of predicting tumor proliferative activity and pathological grading of brain gliomas based on samples obtained front proton MR spectroscopy-guided stereotactic biopsy also remains unclear. The purpose of this study was to evaluate the usefulness of single-voxel MR spectroscopy-guided stereotactic biopsy for cerebral gliomas and to correlate the findings of MR spectroscopy with proliferative activity (measured by Ki-67 labeling index) of tumors and pathological diagnosis. Methods: Localized proton spectra were obtained before stereotactic/surgical biopsy in 7 patients with glioma (8 lesions). Metabolic values in the spectra were measured semiquantitatively and correlated with the Ki-67 labeling index and pathological grade of each surgical specimen. Results: MR spectroscopy-guided biopsy was effective in obtaining a representative specimen for accurate pathological diagnosis in all patients, including 1 patient with multifocal glioma and 2 with diffusely infiltrated gliomas (gliomatosis cerebri). Those lesions with higher choline complex/creatine ratio (Cho/Cr) and lower N-acetyl-L-aspartate/creatine values in MR spectroscopy were higher grade tumors. Higher Ki-67 labeling index (indicating higher proliferative activity of tumor) with higher Cho/Cr ratios in MR spectroscopy were significantly correlated with tumor grade. Conclusions: MR spectroscopy-guided biopsy was effective in obtaining a representative specimen for accurate pathological diagnosis, and the Clio/Cr ratio of MR spectra and Ki-67 labeling index were reliable predictors of glioma grade.
原文英語
頁(從 - 到)448-458
頁數11
期刊Journal of the Formosan Medical Association = Taiwan yi zhi
103
發行號6
出版狀態已發佈 - 六月 2004

ASJC Scopus subject areas

  • Medicine(all)

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