Proteomic identification of lower apolipoprotein A-I in Alzheimer's disease

Hsing Cheng Liu, Chaur Jong Hu, Jan Gowth Chang, Shing Ming Sung, Long Shyong Lee, Rey Yue Yuan, Sy Jye Leu

研究成果: 雜誌貢獻文章同行評審

64 引文 斯高帕斯(Scopus)


Many researches have been trying to find the potential biomarkers for Alzheimer's disease (AD). We hereby used the proteomics method to search for protein expression differences in the serum between AD patients and controls. We enrolled 59 AD patients and 74 age- and sex-matched controls in this study. Ten AD patients and 10 controls were selected for proteomic analysis. Apolipoprotein A-I (ApoA-I) was found to have a lower expression in the AD group by a proteomics two-dimensional gel electrophoresis study. We further measured the serum ApoA-I level which was significantly lower in the AD patients (112.29 ± 21.33 mg/dl) in comparison to the controls (144.53 ± 19.91 mg/dl; p <0.0002). Lower serum ApoA-I levels might be a potential biomarker for AD.

頁(從 - 到)155-161
期刊Dementia and Geriatric Cognitive Disorders
出版狀態已發佈 - 二月 2006

ASJC Scopus subject areas

  • 神經心理學與生理心理學
  • 老年病學和老年學


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