Proteoglycan Endocan: A multifaceted therapeutic target in Cancer

Ke Fan Pan, Yi Chieh Yang, Wei Jiunn Lee, Kuo Tai Hua, Ming Hsien Chien

研究成果: 雜誌貢獻回顧型文獻同行評審

摘要

Endocan is known to be a circulating dermatan sulfate proteoglycan that regulates endothelial cell function. Dysregulation of endocan expression is observed not only in the tumor vasculature but also in cancer cells. Accumulating evidence has revealed that disordered endocan facilitates cancer progression via enhancing cancer cell proliferation, cell mobility, and cancer stemness properties. Recently, various interacting proteins and diverse subcellular localizations of endocan were identified in cancer cells. Herein, we summarize the application of endocan in cancer diagnoses and prognoses using serum and tumor specimens. We further discuss that the aberrant molecular characteristics of endocan may be due to the mislocalization of endocan in cancer cells. Defining the specific cellular roles of endocan will provide a promising diagnostic factor and therapeutic target for cancer patients.
原文英語
文章編號188672
期刊Biochimica et Biophysica Acta - Reviews on Cancer
1877
發行號1
DOIs
出版狀態已發佈 - 1月 2022

ASJC Scopus subject areas

  • 腫瘤科
  • 遺傳學
  • 癌症研究

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