Protective effects of sesamol and ferulic acid on the formation of endogenous trans-arachidonic acid in hAPP J20 mice

B.-Y. Hsu, W.-L. Hung, C.-T. Ho, I.H. Cheng, L.S. Hwang

研究成果: 雜誌貢獻文章同行評審

5 引文 斯高帕斯(Scopus)

摘要

Alzheimer's disease (AD) is characterized by progressive formation of β-amyloid peptide (Aβ) in the brain. Aβ induced oxidative stress may cause cis-. trans isomerization of fatty acids. However, the research on AD rarely discusses the correlation between the formation of endogenous trans fatty acids (TFA) and the progression of AD. Thus, the goal of this research was to study the difference of trans-arachidonic acid (TAA) composition of brain and hippocampus between J20 mice (AD mouse model) and B6 mice (wild type control). Our results showed that the endogenous TAA (8-. trans-C20:4) of brain and hippocampus in 9 months old J20 mice was significantly higher than B6 mice which indicated that there was a positive relationship between the formation of endogenous TAA and AD. In addition, this study also revealed that sesamol and ferulic acid could reduce the formation of 8. -trans-C20:4. Thus, they might be employed as potential functional food ingredients for the prevention of AD. © 2015 Elsevier Ltd.
原文英語
頁(從 - 到)378-385
頁數8
期刊Journal of Functional Foods
16
DOIs
出版狀態已發佈 - 2015
對外發佈Yes

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