Protective effects of fucoxanthin on ultraviolet B-induced corneal denervation and inflammatory pain in a rat model

Shiu Jau Chen, Ching Ju Lee, Tzer Bin Lin, Hsien Yu Peng, Hsiang Jui Liu, Yu Shan Chen, Kuang Wen Tseng

研究成果: 雜誌貢獻文章

4 引文 斯高帕斯(Scopus)

摘要

Fucoxanthin is a carotenoid with many pharmaceutical properties that is found in brown seaweed. However, the effects of fucoxanthin on corneal innervation and intense eye pain have not been extensively examined. To clarify the protective roles and underlying mechanisms of fucoxanthin on ocular lesions, we investigated the beneficial effects and mechanisms by which fucoxanthin ameliorates ultraviolet B (UVB)-induced corneal denervation and trigeminal pain. Treatment with fucoxanthin enhanced the expression of nuclear factor erythroid 2-related factor 2 in the cornea. Inhibition of typical denervation and epithelial exfoliation in the cornea were observed in rats treated with fucoxanthin following UVB-induced nerve disorders. Moreover, the active phosphorylated form of p38 MAP kinase (pp38) and the number of glial fibrillary acidic protein (GFAP)-positive neural cells were significantly reduced. Decreased expression of neuron-selective transient receptor potential vanilloid type 1 (TRPV1) in the trigeminal ganglia neurons was also demonstrated in rats treated with fucoxanthin after UVB-induced keratitis. Symptoms of inflammatory pain, including difficulty in opening the eyes and eye wipe behaviour, were also reduced in fucoxanthin-treated groups. Pre-treatment with fucoxanthin may protect the eyes from denervation and inhibit trigeminal pain in UVB-induced photokeratitis models.
原文英語
文章編號152
期刊Marine Drugs
17
發行號3
DOIs
出版狀態已發佈 - 三月 5 2019

ASJC Scopus subject areas

  • Drug Discovery

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