Protective effects of anthocyanins against amyloid β-peptide-induced damage in neuro-2A Cells

Ping Hsiao Shih, Chi Hao Wu, Chi-Tai Yeh, Gow Chin Yen

研究成果: 雜誌貢獻文章同行評審

55 引文 斯高帕斯(Scopus)


Alzheimer's disease is neuropathologically characterized by amyloid β-protein (Aβ) deposition, resulting in neurotoxicity. Herein, we focused on the prevention of anthocyanins from amyloid-mediated neurodysfunction. The data demonstrated that combined exposure of Aβ 1-40 and Aβ 25-35 to Neuro-2A cells resulted in reactive oxygen species (ROS) production and perturbation of calcium homeostasis. The expressions of LXRα, ApoE, ABCA1, and seladin-1 genes were significantly down-regulated upon Aβ challenge. β-Secretase, the rate-limiting enzyme that catalyzes amyloid precursor protein transform to Aβ, was up-regulated by Aβ treatment. For the duration of Aβ stimulation, malvidin (Mal) or oenin (Oen; malvidin-3-O-glucoside) was added, and the protective effects were observed. Mal and Oen showed protective effects against Aβ-induced neurotoxicity through blocking ROS formation, preserving Ca 2+ homeostasis, and preventing Aβ-mediated perturbation of certain genes involved in Aβ metabolism and cellular defense. The present study implicates anthocyanin as a potential therapeutic candidate for the prevention of amyloid-mediated neurodysfunction.
頁(從 - 到)1683-1689
期刊Journal of Agricultural and Food Chemistry
出版狀態已發佈 - 3月 9 2011

ASJC Scopus subject areas

  • 農業與生物科學 (全部)
  • 化學 (全部)


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