Protective effect of Panax quinquefolium against chemical-induced gastric mucosal injury

Cheng Chen Hsu, Fu An Chen, Borcherng Su, Li Chin Lin, Hirofumi Matsui, Mei Chich Hsu

研究成果: 雜誌貢獻文章同行評審

1 引文 斯高帕斯(Scopus)

摘要

The American ginseng (Panax quinquefolium L.) is widely used in the oriental traditional medicine. The present study investigates the protection effects of Panax quinquefolium extract granule (PQEG) against chemical-induced gastric mucosal injury. In vitro cell damage was induced by incubating rat gastric mucosal cells, RGM1, with indomethacin (INDO) and quantitated by methylthiazole-tetrazolium (MTT) assay. In vivo gastric damage was induced by 70 % ethanol 10 mL/kg and the ulcer index was calculated the gastric mucosal damage percentage. In vitro study, Panax quinquefolium extract granule revealed significant protection on rat gastric mucosal cells, RGM1, from indomethacin-caused cytotoxicity, with an EC50 of 694.4 mg/kg (95 % CL: 582.2-872.6). In vivo studies showed pretreatment with Panax quinquefolium extract granule caused a significant and dose-dependent inhibition of ethanol-induced gastric mucosal damage, with an ED50 of 588.7 mg/kg (95 % CL: 426.8-850.3). In conclusion, Panax quinquefolium treatment shows protective role in indomethacin- induced gastric mucosa cell injury in vitro and ethanol-induced gastric mucosa lesions in vivo.

原文英語
頁(從 - 到)843-846
頁數4
期刊Asian Journal of Chemistry
24
發行號2
出版狀態已發佈 - 2012

ASJC Scopus subject areas

  • 化學 (全部)

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