Protective effect of melatonin on liver ischemia-reperfusion induced pulmonary microvascular injury in rats

M. H. Chiu, C. L. Su, C. F. Chen, K. H. Chen, D. Wang, J. J. Wang

研究成果: 雜誌貢獻文章

8 引文 斯高帕斯(Scopus)

摘要

Objective: Reactive oxygen species generated during liver reperfusion have been implicated in remote lung injury. In this study, we evaluate the protective effects of melatonin pretreatment against the increased pulmonary microvascular permeability. Methods: Male Sprague-Dawley rats were divided into three groups: shame-operated, liver ischemia-reperfusion (I/R), and melatonin pretreated (15 mg/kg, intraperitoneally) 15 minutes prior to the liver I/R). The duration of ischemia was 30 minutes, followed by 2 hours of reperfusion. Lungs were isolated in situ and parameters of the capillary filtration coefficient (K fc), lung wet-to-dry weight ratio (W/D), lung weight-to-body weight (LW/BW), and protein concentration in bronchial lavage fluid (PCBAL), the percentage of macrophages and neutrophils in bronchial lavage fluid (BALF), and lung tissue malonedealdehyde were used to assess the lung injury. Results: Liver I/R-induced lung injury was noted by the markedly increased K fc, W/D, LW/BW, PCBAL, and the presence of neutrophils and macrophages in BALF. Lipid peroxidation was also increased (P
原文英語
頁(從 - 到)962-965
頁數4
期刊Transplantation Proceedings
44
發行號4
DOIs
出版狀態已發佈 - 五月 2012

ASJC Scopus subject areas

  • Surgery
  • Transplantation

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