Protective effect of magnolol-loaded polyketal microparticles on lipopolysaccharide-induced acute lung injury in rats

Tsuimin Tsai, Chen Yu Kao, Chun Liang Chou, Lu Chun Liu, Tz Chong Chou

研究成果: 雜誌貢獻文章同行評審

7 引文 斯高帕斯(Scopus)

摘要

Magnolol has shown inhibitory effects on NO production and TNF-alpha production in lipopolysaccharide (LPS)-activated macrophages and LPS-induced acute lung injury; however, the poor solubility of magnolol has hindered its clinical success. In this study, magnolol-loaded microparticles were prepared via single emulsion method from a polyketal polymer, termed PK3. The particle sizes of magnolol-loaded PK3 microparticle is 3.73 ± 0.41 μm, and was suitable for phagocytosis by macrophages and pulmonary drug delivery. PK3 microparticles exhibited excellent biocompatibility both in vitro and in vivo. More importantly, intratracheal delivery of these magnolol-loaded microparticles significantly reduced the lung inflammatory responses at low dosage of magnolol (0.5 mg/kg), and have great clinical potential in treating acute lung injury.

原文英語
頁(從 - 到)401-411
頁數11
期刊Journal of Microencapsulation
33
發行號5
DOIs
出版狀態已發佈 - 七月 3 2016

ASJC Scopus subject areas

  • 生物工程
  • 醫藥 (全部)
  • 藥學科學
  • 物理與理論化學
  • 有機化學
  • 膠體和表面化學

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