Protective effect of Acacia confusa bark extract and its active compound gallic acid against carbon tetrachloride-induced chronic liver injury in rats

Yu Tang Tung, Jyh Horng Wu, Chi Chang Huang, Hsiang Chi Peng, Ya Ling Chen, Suh-Ching Yang, Shang Tzen Chang

研究成果: 雜誌貢獻文章

75 引文 (Scopus)

摘要

Acacia confusa Merr. (Leguminosae), a species native to Taiwan, is widely distributed on the hills and lowlands of Taiwan, and has been traditionally used as a medicine. The hepatoprotective effects of A. confusa bark extract (ACBE) and its active constituent gallic acid were evaluated against carbon tetrachloride (CCl4)-induced hepatotoxicity in rats. CCl4-induced hepatic pathological damage and significantly increased the levels of aspartate aminotransferase (AST), alanine aminotransferase (ALT) and malondialdehyde (MDA) in plasma, and cytochrome P4502E1 (CYP2E1) protein expression in hepatic samples, and decreased the activities of superoxide dismutase (SOD), glutathione peroxidase (GPX) and catalase (CAT) in erythrocytes. Treatment with ACBE, gallic acid or silymarin could decrease significantly the AST, ALT, and MDA levels in plasma, and CYP2E1 expression in liver tissues, and increase the activities of SOD and GPX in erythrocyte when compared with CCl4-treated group. Liver histopathology also showed that ACBE, gallic acid or silymarin could significantly reduce the incidence of liver lesions induced by CCl4. These results suggested that the ACBE and gallic acid exhibit potent hepatoprotection against CCl4-induced liver damages in rats, and the hepatoprotective effects of ACBE and gallic acid may be due to the modulation of antioxidant enzymes activities and inhibition of lipid peroxidation and CYP2E1 activation. Crown
原文英語
頁(從 - 到)1385-1392
頁數8
期刊Food and Chemical Toxicology
47
發行號6
DOIs
出版狀態已發佈 - 六月 2009

指紋

Acacia confusa
Acacia
Gallic Acid
carbon tetrachloride
Carbon Tetrachloride
gallic acid
Liver
protective effect
Rats
bark
Cytochromes
liver
rats
Wounds and Injuries
Silymarin
extracts
cytochromes
silymarin
hepatoprotective effect
Glutathione Peroxidase

ASJC Scopus subject areas

  • Food Science
  • Toxicology

引用此文

Protective effect of Acacia confusa bark extract and its active compound gallic acid against carbon tetrachloride-induced chronic liver injury in rats. / Tung, Yu Tang; Wu, Jyh Horng; Huang, Chi Chang; Peng, Hsiang Chi; Chen, Ya Ling; Yang, Suh-Ching; Chang, Shang Tzen.

於: Food and Chemical Toxicology, 卷 47, 編號 6, 06.2009, p. 1385-1392.

研究成果: 雜誌貢獻文章

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abstract = "Acacia confusa Merr. (Leguminosae), a species native to Taiwan, is widely distributed on the hills and lowlands of Taiwan, and has been traditionally used as a medicine. The hepatoprotective effects of A. confusa bark extract (ACBE) and its active constituent gallic acid were evaluated against carbon tetrachloride (CCl4)-induced hepatotoxicity in rats. CCl4-induced hepatic pathological damage and significantly increased the levels of aspartate aminotransferase (AST), alanine aminotransferase (ALT) and malondialdehyde (MDA) in plasma, and cytochrome P4502E1 (CYP2E1) protein expression in hepatic samples, and decreased the activities of superoxide dismutase (SOD), glutathione peroxidase (GPX) and catalase (CAT) in erythrocytes. Treatment with ACBE, gallic acid or silymarin could decrease significantly the AST, ALT, and MDA levels in plasma, and CYP2E1 expression in liver tissues, and increase the activities of SOD and GPX in erythrocyte when compared with CCl4-treated group. Liver histopathology also showed that ACBE, gallic acid or silymarin could significantly reduce the incidence of liver lesions induced by CCl4. These results suggested that the ACBE and gallic acid exhibit potent hepatoprotection against CCl4-induced liver damages in rats, and the hepatoprotective effects of ACBE and gallic acid may be due to the modulation of antioxidant enzymes activities and inhibition of lipid peroxidation and CYP2E1 activation. Crown",
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AB - Acacia confusa Merr. (Leguminosae), a species native to Taiwan, is widely distributed on the hills and lowlands of Taiwan, and has been traditionally used as a medicine. The hepatoprotective effects of A. confusa bark extract (ACBE) and its active constituent gallic acid were evaluated against carbon tetrachloride (CCl4)-induced hepatotoxicity in rats. CCl4-induced hepatic pathological damage and significantly increased the levels of aspartate aminotransferase (AST), alanine aminotransferase (ALT) and malondialdehyde (MDA) in plasma, and cytochrome P4502E1 (CYP2E1) protein expression in hepatic samples, and decreased the activities of superoxide dismutase (SOD), glutathione peroxidase (GPX) and catalase (CAT) in erythrocytes. Treatment with ACBE, gallic acid or silymarin could decrease significantly the AST, ALT, and MDA levels in plasma, and CYP2E1 expression in liver tissues, and increase the activities of SOD and GPX in erythrocyte when compared with CCl4-treated group. Liver histopathology also showed that ACBE, gallic acid or silymarin could significantly reduce the incidence of liver lesions induced by CCl4. These results suggested that the ACBE and gallic acid exhibit potent hepatoprotection against CCl4-induced liver damages in rats, and the hepatoprotective effects of ACBE and gallic acid may be due to the modulation of antioxidant enzymes activities and inhibition of lipid peroxidation and CYP2E1 activation. Crown

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