Protection of DNA ends by telomeric 3′ G-tail sequences

研究成果: 雜誌貢獻文章

16 引文 斯高帕斯(Scopus)

摘要

The extreme ends of eukaryotic chromosomes contain 3′ extensions in the form of single-stranded G-rich repeats, referred to as telomeric 3′ G-tails or overhangs. Increasing evidence has suggested that telomeric 3′ G-tails can adopt a G-quadruplex conformation both in vitro and in vivo. However, the role of G-quadruplexes on the structure and function of telomeric 3′ G-tails remains unclear. In the current study, we showed that the human telomeric 3′ G-tail sequence protected the duplex DNA ends in cis from being recognized as double strand breaks. This protection is dependent on the G-quadruplex conformation of the 3′ G-tail sequence. These results suggest that the ability of telomeric 3′ G-tails to adopt the end-protecting G-quadruplex conformation may be one of the reasons for the existence of the evolutionarily conserved G-stretch motifs in telomeric DNA sequences.
原文英語
頁(從 - 到)18786-18792
頁數7
期刊Journal of Biological Chemistry
282
發行號26
DOIs
出版狀態已發佈 - 六月 29 2007
對外發佈Yes

ASJC Scopus subject areas

  • Biochemistry

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